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Longitudinal assessment of thyroid function in dogs with hypoadrenocorticism: Clinical outcomes and prevalence of autoantibodies.
J Vet Intern Med
December 2024
Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Background: Knowledge about primary hypoadrenocorticism coexisting with immune-mediated thyroiditis (Schmidt's syndrome) in dogs is limited.
Objective: To evaluate thyroid function in dogs with naturally occurring hypoadrenocorticism before and during treatment.
Animals: Sixty-six client-owned dogs.
A Case of Myxedema Coma and Adrenal Insufficiency Post Pembrolizumab.
Case Rep Endocrinol
July 2024
Endocrinology Division Louis Pasteur Hospital, Le Coudray, France.
Article Synopsis
- Immune checkpoint inhibitors (ICIs) like pembrolizumab have notable clinical advantages but can cause serious side effects known as immune-related adverse events (irAEs), affecting various organ systems.
- A case study of a female patient revealed that she experienced myxedema coma (MC) and adrenal insufficiency (AI) four months after stopping treatment with pembrolizumab, necessitating treatment with levothyroxine and hydrocortisone.
- This highlights the need for careful monitoring of patients on ICIs for potential endocrine disorders, as they can lead to severe health complications if not detected early.
A novel missense mutation in the AIRE gene underlying autoimmune polyglandular syndrome type 1.
Immunogenetics
February 2024
Facultad de Ciencias Químicas, Departamento de Química Teórica y Computacional, Universidad Nacional de Córdoba, Córdoba, Argentina.
The immune regulator gene AIRE plays an essential role in the establishment of immune tolerance and the prevention of autoimmunity. This transcription factor plays a critical role in promoting self-tolerance in the thymus by regulating the expression of a large number of self-antigens that share the common feature of being tissue-restricted in their expression pattern in the periphery. Dysfunction of AIRE in humans causes a rare disease, autoimmune polyglandular syndrome type 1 (APS1), characterized by an autoimmune response against peripheral tissues, particularly endocrine tissues.
View Article and Find Full Text PDFAutoimmune polyendocrine syndromes associated with autoimmune rheumatic diseases.
Reumatologia
August 2023
Department of Gynaecological Endocrinology, Medical University of Warsaw, Poland.
Autoimmune polyendocrine syndromes (APSs), also called autoimmune polyglandular syndromes, are a group of autoimmune diseases characterized by the co-occurrence of dysfunctions of several (at least two) endocrine glands. They develop under the influence of environmental factors in genetically predisposed people. Autoimmune polyendocrine syndromes may accompany autoimmune rheumatic diseases and worsen their course - APS-2 and APS-3 are the most common.
View Article and Find Full Text PDFManagement of Adrenal Deficiency and Shock in a Patient With Polyglandular Autoimmune Syndrome Type II.
Cureus
July 2023
Hospital Medicine, Endocrinology, Premier Health Network, Dayton, USA.
Polyglandular autoimmune syndrome (PAS) is a rare disorder characterized by the autoimmune destruction of multiple endocrine glands. Type II PAS is the most common of the PAS subtypes and is characterized by Addison's disease, autoimmune thyroid disease, and type I diabetes mellitus. Disease manifestations are predominantly seen in young adulthood with an emerging endocrine disorder; however, a host of other autoimmune conditions can also be present before endocrine organ dysfunction.
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