AI Article Synopsis
- The review examines how neurosteroids, particularly progesterone and allopregnanolone, influence pain regulation, especially in the spinal cord's dorsal horn, a key area for processing pain.
- It highlights the mechanisms by which these neuroactive steroids can reduce nociceptive (pain from harm) and neuropathic (nerve damage-related) pain.
- The focus is on how progesterone and its derivative can mitigate negative effects and pain behaviors following nervous system injury in experimental settings.
Article Abstract
The present review discusses the potential role of neurosteroids/neuroactive steroids in the regulation of nociceptive and neuropathic pain, and recapitulates the current knowledge on the main mechanisms involved in the reduction of pain, especially those occurring at the dorsal horn of the spinal cord, a crucial site for nociceptive processing. We will make special focus on progesterone and its derivative allopregnanolone, which have been shown to exert remarkable actions in order to prevent or reverse the maladaptive changes and pain behaviors that arise after nervous system damage in various experimental neuropathic conditions.
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| http://dx.doi.org/10.1016/j.steroids.2016.04.005 | DOI Listing |
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