Purpose: This study investigated a fundamentally new type of responsive MRI contrast agent for molecular imaging that alters T exchange (T ) properties after interacting with a molecular biomarker.
Methods: The contrast agent Tm-DO3A-oAA was treated with nitric oxide (NO) and O . The R and R relaxation rates of the reactant and product were measured with respect to concentration, temperature, and pH. Chemical exchange saturation transfer (CEST) spectra of the reactant and product were acquired using a 7 Tesla (T) MRI scanner and analyzed to estimate the chemical exchange rates and r relaxivities.
Results: The reaction of Tm-DO3A-oAA with NO and O caused a 6.4-fold increase in the r relaxivity of the agent, whereas r relaxivity remained unchanged, which demonstrated that Tm-DO3A-oAA is a responsive T agent. The effects of pH and temperature on the r relaxivities of the reactant and product supported the conclusion that the product's benzimidazole ligand caused the agent to have a fast chemical exchange rate relative to the slow exchange rate of the reactant's ortho-aminoanilide ligand.
Conclusions: T MRI contrast agents are a new type of responsive agent that have good detection sensitivity and specificity for detecting a biomarker, which can serve as a new tool for molecular imaging. Magn Reson Med 77:1665-1670, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
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| http://dx.doi.org/10.1002/mrm.26250 | DOI Listing |
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