Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2143/AC.71.2.3141857 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neuronal constitutive endolysosomal perforations enable α-synuclein aggregation by internalized PFFs.
J Cell Biol
February 2025
Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
Endocytosis, required for the uptake of receptors and their ligands, can also introduce pathological aggregates such as α-synuclein (α-syn) in Parkinson's Disease. We show here the unexpected presence of intrinsically perforated endolysosomes in neurons, suggesting involvement in the genesis of toxic α-syn aggregates induced by internalized preformed fibrils (PFFs). Aggregation of endogenous α-syn in late endosomes and lysosomes of human iPSC-derived neurons (iNs), seeded by internalized α-syn PFFs, caused the death of the iNs but not of the parental iPSCs and non-neuronal cells.
View Article and Find Full Text PDFMacular hole closure with a vertical joint of the inner limiting membrane (ILM).
BMJ Case Rep
December 2024
University of Otago, Dunedin, New Zealand.
This case report describes an unexpected surgical outcome with the presence of a vertical joint of the inner limiting membrane (ILM) after a vitrectomy using the inverted internal limiting membrane flap technique. A woman presented with 5 months of vision loss in the left eye. The visual acuities were 6/9 in the right eye and 6/75 in the left eye.
View Article and Find Full Text PDFNecrotizing fasciitis that led to unexpected and fulminant deterioration in less than 24 hours: a case report.
J Int Med Res
December 2024
Department of Trauma Surgery and Orthopedics, BG Klinikum Duisburg, University Duisburg-Essen, Germany.
Necrotizing fasciitis (NF) is a rapidly progressing condition with a high mortality rate. The poor prognosis is often due to delayed diagnosis, which is typically made clinically or radiologically. This case report highlights a rare instance of fulminant NF with an atypical presentation-no initial clinical signs and an unusual radiological appearance.
View Article and Find Full Text PDFUnexpected peritoneal metastases diagnosed at the time of primary colon cancer resection: controversies regarding options for management.
J Gastrointest Oncol
October 2024
Department of Colorectal Surgery, Ellen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, FL, USA.
Peritoneal metastases synchronously occurring in the patient with primary colon cancer causes that patient to be at high risk for subsequent disease progression within the abdomen and pelvis. If peritoneal metastases are preoperatively diagnosed, patients are likely to be treated with neoadjuvant chemotherapy with or without biological therapy prior to cytoreductive surgery (CRS). However, if one only considers patients with peritoneal metastases unexpectedly identified at the time of primary colon cancer resection, the optimal management strategy is neither standardized nor evidence based.
View Article and Find Full Text PDFVentricular rupture during the removal of Impella 5.5 in a patient with fulminant myocarditis.
J Cardiol Cases
November 2024
Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan.
Unlabelled: Ventricular perforation or rupture caused by Impella (Abiomed Inc., Danvers, MA, USA) is extremely rare. The Japanese registry of Impella usage reported that the incidence of perforation was 0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!