AI Article Synopsis
- Four new diterpenoid compounds were isolated from the plant Euphorbia rapulum, identified as 1-epi-9-hydroxydepressin (1), 1-epi-8-hydroxydepressin (2), 2,13,9-trihydroxy-labda-8(17),12(E),14-triene (3), and tagalsin I (4).
- The structures of these compounds were determined using various spectroscopic techniques.
- Compound 4 demonstrated moderate selective cytotoxic activity against the MCF-7 cancer cell line, recording an IC50 value of 31.8 μM.
Article Abstract
Four new diterpenoids named 1-epi-9-hydroxydepressin (1), 1-epi-8-hydroxydepressin (2), 2,13,9-trihydroxy-labda-8(17),12(E),14-triene (3) and tagalsin I (4) were isolated from Euphorbia rapulum. The structures of these compounds were elucidated by means of various spectroscopic methods. All the isolated compounds were evaluated for cytotoxic activities against HepG2, MCF-7, and C6 cell lines, and compound 4 showed moderate selective activity against MCF-7 cell line with an IC50 value of 31.8 μM.
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| http://dx.doi.org/10.1080/10286020.2016.1170813 | DOI Listing |
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