Approximately 50% of Japanese individuals who develop venous thrombosis have reduced activities of protein S, the major component of the Activated Protein C (APC) anticoagulant system. The significance of the measurement of protein S-specific activity and its practical use will be discussed.
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BNT162b2 mRNA vaccine elicits robust virus-specific antibodies but poor cross-protective CD8 memory T cell responses in adolescents with type 1 diabetes.
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January 2025
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan; Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan. Electronic address:
Background: COVID-19 mRNA vaccines have demonstrated 95 % efficacy in the general population. However, their immunogenicity in adolescents with Type 1 Diabetes (T1D), who exhibit weaken immune responses, remains insufficiently explored.
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Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
Rett syndrome (RS) is a rare neurodevelopmental disorder primarily caused by mutations in the X-linked methyl-CpG binding protein 2 (MECP2) gene, responsible for encoding MECP2 which plays a pivotal role in regulating gene expression. The neurological and non-neurological manifestations of RS vary widely in severity depending on the specific mutation type. Bone complications, mostly scoliosis but also osteoporosis, hip displacement, and a high rate of fractures, are among the most prevalent non-neurological comorbidities observed in girls with RS.
View Article and Find Full Text PDFEnhanced Photothermal/Immunotherapy under NIR Irradiation Based on Hollow Mesoporous Responsive Nanomotor.
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Laboratory of Electromechanical Integrated Manufacturing of High-performance Electronic Equipment, School of Mechano-Electronic Engineering, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710071, China.
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View Article and Find Full Text PDFAn institution-wide mixed methods assessment of healthcare transition.
Health Care Transit
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Department of Pediatrics, University of Pittsburgh School of Medicine, 3550 Terrace St, Pittsburgh, PA, 15213, United States.
Background: Healthcare transition (HCT) is the process of moving a patient from pediatric, parent-supervised care to an independent, adult-centered model. This study assesses current HCT activities and explores the educational and system-based needs for effective HCT processes in a single institution.
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