AI Article Synopsis
- This study presents a method for synthesizing phenanthridinones using palladium catalysis, by coupling aniline and amide through C-C and C-N bond formation in one step.
- The process involves breaking four bonds and creating two new ones, all under mild conditions without the need for additional ligands.
- The reaction is environmentally friendly, yielding only nitrogen gas and water as byproducts, and it works efficiently with various aniline and amide types, even at a larger, gram-scale production.
Article Abstract
This work reports palladium-catalyzed phenanthridinone synthesis using the coupling of aniline and amide by formation of C-C and C-N bonds in a one-pot fashion via dual C-H bond activation. It involves simultaneous cleavage of four bonds and the formation of two new bonds. The present protocol is ligand-free, takes place under mild reaction conditions, and is environmentally benign as nitrogen gas and water are the only side products. This transformation demonstrates a broad range of aniline and amide substrates with different functional groups and has been scaled up to gram level.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.joc.6b00378 | DOI Listing |
Publication Analysis
Top Keywords
phenanthridinone synthesis
8
c-h bond
8
bond activation
8
aniline amide
8
palladium-catalyzed deaminative
4
deaminative phenanthridinone
4
synthesis aniline
4
aniline c-h
4
activation work
4
work reports
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!