Human monocytic ehrlichiosis is a febrile illness caused by Ehrlichia chaffeensis, an intracellular bacterium transmitted by ticks. In Mexico, a case of E. chaffeensis infection in an immunocompetent 31-year-old woman without recognized tick bite was fatal. This diagnosis should be considered for patients with fever, leukopenia, thrombocytopenia, and elevated liver enzyme levels.
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http://dx.doi.org/10.3201/eid2205.151217 | DOI Listing |
Rev Bras Parasitol Vet
January 2025
Programa de Pós-graduação em Ciências Veterinárias, Faculdade de Medicina Veterinária - FAVET, Universidade Federal de Mato Grosso - UFMT Cuiabá, MT, Brasil.
Canine monocytic ehrlichiosis (CME) is an infectious disease that causes hematological changes in dogs. This study investigated the correlations between hematological and hemorheological parameters, serum proteins, and triglycerides in dogs with CME. Fifty-nine blood and/or bone marrow samples were collected from dogs with or without clinical signs of CME.
View Article and Find Full Text PDFPathogens
December 2024
Centro di Referenza Nazionale per Anaplasma, Babesia Rickettsia, e Theileria (C.R.A.Ba.R.T.), Istituto Zooprofilattico Sperimentale della Sicilia "A. Mirri", 90129 Palermo, Italy.
Vector-borne diseases represent a serious threat to human and animal health, especially where environmental conditions favor pathogen-carrying vectors. Dogs serve as natural hosts for two tick-borne pathogens: , which causes canine monocytic ehrlichiosis, and spotted fever group (SFG) spp., a zoonotic threat in the Mediterranean region.
View Article and Find Full Text PDFVet Parasitol
December 2024
Postgraduate Program in Animal Science, Franca University (UNIFRAN), Franca, São Paulo, Brazil. Electronic address:
Canine monocytic ehrlichiosis (CME), induced by Ehrlichia canis, is an important infectious disease in dogs, characterized by various clinical signs and consequent immune dysfunction. This study aimed to characterize nuclear morphology, chromatin compaction, histone H3 acetylation, and DNA methylation in lymphocytes from dogs naturally infected with E. canis, compared with healthy controls.
View Article and Find Full Text PDFVet Sci
December 2024
Laboratory of Veterinary Parasitology and Clinical Analysis, Academic Unit of Agricultural Sciences, Federal University of Jataí, Jataí 75801-615, Goiás, Brazil.
Canine monocytic ehrlichiosis (CME) is an infectious disease caused by , a globally recognized obligate intracellular bacterium. In addition to dogs, other animals, including humans, may be affected. Despite its epidemiological importance and impact on public health, there is currently no commercial vaccine against .
View Article and Find Full Text PDFMicrobiol Res
December 2024
Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, United States. Electronic address:
Ehrlichia chaffeensis is an obligatory intracellular bacterium that infects monocytes and macrophages and causes human monocytic ehrlichiosis. Ehrlichia translocated factor-3 (Etf-3) is a type IV secretion system effector that binds host-cell ferritin light chain and induces ferritinophagy, thus increasing cellular labile iron pool for Ehrlichia proliferation. To further characterize roles of Etf-3 in Ehrlichia infection, we produced immune libraries of Etf-3-specific nanobodies (Nbs).
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