AI Article Synopsis
- Molecular diffusive membranes, particularly hydrogels, are crucial for biological microfluidic applications due to their benefits like small molecule diffusion, biocompatibility, and ease of production.
- Hydrogels are integrated into microfluidics through techniques like soft lithography and UV curing, serving various roles in fluid control and biochemical reactions.
- Despite their long-term use, many properties and integration techniques of hydrogels remain underexplored, prompting a review that aims to assist researchers in selecting appropriate methods for hydrogel applications.
Article Abstract
Molecular diffusive membranes or materials are important for biological applications in microfluidic systems. Hydrogels are typical materials that offer several advantages, such as free diffusion for small molecules, biocompatibility with most cells, temperature sensitivity, relatively low cost, and ease of production. With the development of microfluidic applications, hydrogels can be integrated into microfluidic systems by soft lithography, flow-solid processes or UV cure methods. Due to their special properties, hydrogels are widely used as fluid control modules, biochemical reaction modules or biological application modules in different applications. Although hydrogels have been used in microfluidic systems for more than ten years, many hydrogels' properties and integrated techniques have not been carefully elaborated. Here, we systematically review the physical properties of hydrogels, general methods for gel-microfluidics integration and applications of this field. Advanced topics and the outlook of hydrogel fabrication and applications are also discussed. We hope this review can help researchers choose suitable methods for their applications using hydrogels.
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| http://dx.doi.org/10.1039/c6lc00247a | DOI Listing |
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