Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jtcvs.2016.02.068 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
WWC proteins-mediated compensatory mechanism restricts schwannomatosis driven by loss of function.
Sci Adv
January 2025
Institute of Pediatrics, Children's Hospital of Fudan University, and Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
NF2-related schwannomatosis, previously known as neurofibromatosis type 2, is a genetic disorder characterized by nerve tumors due to gene mutations. Mice with deletion develop schwannomas slowly with low penetrance, hence inconvenient for preclinical studies. Here, we show that NF2, by recruiting E3 ubiquitin ligases β-TrCP1/2, promotes WWC1-3 ubiquitination and degradation.
View Article and Find Full Text PDFHypoxia as a medicine.
Sci Transl Med
January 2025
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Oxygen is essential for human life, yet a growing body of preclinical research is demonstrating that chronic continuous hypoxia can be beneficial in models of mitochondrial disease, autoimmunity, ischemia, and aging. This research is revealing exciting new and unexpected facets of oxygen biology, but translating these findings to patients poses major challenges, because hypoxia can be dangerous. Overcoming these barriers will require integrating insights from basic science, high-altitude physiology, clinical medicine, and sports technology.
View Article and Find Full Text PDFInvestigation of the Validity and Reliability of the Turkish Version of the Basic Activities of Daily Living Questionnaire in Preschool Children.
Occup Ther Int
January 2025
Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Türkiye.
Basic Activities of Daily Living-Preschool Period Tool BADL-P) is a fast and quick test that does not require a special environment, where activities of daily living (ADLs) in preschool children are questioned. The aim of the study was to conduct a Turkish reliability and cultural adaptation of the BADL-P. The study was conducted among 211 parents of preschool children.
View Article and Find Full Text PDFEditorial: 73rd annual meeting of the Italian society of physiology: advancement in basic and translational physiology.
Front Physiol
January 2025
Department of Biology, University of Pisa, Pisa, Italy.
Endoscopic surgery affects the gut microbiota and its metabolism in breast cancer patients.
Front Microbiol
January 2025
The First Clinical School of Hainan Medical University, Department of Breast Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, China.
Background: Despite the advantages of endoscopic surgery in reducing trauma and enhancing recovery for breast cancer patients, its impact on gut microbiota, which is crucial for health and estrogen metabolism, remains unclear. Further investigation is necessary to fully understand this impact and its implications.
Materials And Methods: Between June and December 2022, fecal samples were collected from 20 patients who underwent endoscopic surgery.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!