AI Article Synopsis
- Previous research suggests that the CSTC circuit dysfunction is linked to OCD, but newer studies indicate that broader brain systems, including the limbic system and salience network, may also be involved.
- The study examined 28 unmedicated OCD patients and 28 matched controls using resting state fMRI to assess spontaneous brain activity and its relation to OCD symptom severity.
- Results revealed increased neuronal activity in specific regions of the brain for OCD patients, with reduced activity in the right insula, which was strongly correlated with OCD symptom severity, suggesting a more complex understanding of OCD pathophysiology beyond the traditional CSTC framework.
Article Abstract
Background: Previous neuroimaging data indicated that the dysfunction in cortico-striato-thalamo-cortical (CSTC) circuit contributed to the neuropathological mechanism of obsessive-compulsive disorder (OCD). Whereas, emerging work has shown that the pathophysiology of OCD might be related to more widely distributed large-scale brain systems including limbic system and the salience network. This study aims to investigate the aberrant spontaneous neuronal activity within the whole brain, and its association with the symptom severity for unmedicated OCD patients.
Method: Twenty-eight unmedicated OCD adults and twenty-eight matched healthy controls were recruited for a resting state functional magnetic resonance imaging (fMRI) study. The amplitude of low-frequency fluctuation (ALFF) analysis over whole brain was performed to examine the intrinsic cerebral activity of subjects. In addition, we conducted the voxel-based Pearson's correlative analysis to probe into the relationship between ALFF values and symptom severity for OCD patients.
Results: Our results showed that OCD patients had increased ALFF measures in the left frontopolar cortex and left orbital frontal cortex (OFC), with decreased ALFF values in the right insula. Moreover, the right insular intrinsic activity was significantly correlated with total YBOCS score (r = 0.611, p = 0.002) and compulsion score (r = 0.640, p = 0.001) for OCD patients.
Conclusion: The results showed abnormal intrinsic neuronal activity within CSTC circuit and salience network of OCD patients. Our finding of aberrant insular activity advanced the understanding of OCD pathophysiology beyond the traditional CSTC circuit. To the best of our knowledge, it is the first finding about a reduced insular activity at the resting state for unmedicated OCD patients, which might serve as an informative biomarker for OCD pathophysiology.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833895 | PMC |
| http://dx.doi.org/10.1186/s12888-016-0806-9 | DOI Listing |
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