Generation of a diverse repertoire of antigen receptor specificities via DNA recombination underpins adaptive immunity. In this issue ofGenes&Development, Carmona and colleagues (pp. 909-917) provide novel insights into the origin and function of recombination-activating gene 1 (RAG1) and RAG2, the lymphocyte-specific components of the recombinase involved in the process.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840292 | PMC |
| http://dx.doi.org/10.1101/gad.281014.116 | DOI Listing |
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