AI Article Synopsis
- The study explored the effects of N-acetylcysteine (NAC) and enoxaparin on ovarian tissue damage after torsion/detorsion injury in rats, comparing their effectiveness in preserving ovarian reserve.
- NAC treatment led to a higher number of pre-antral follicles and less tissue damage compared to the enoxaparin group, highlighting NAC's superior protective effects against oxidative stress.
- Both NAC and enoxaparin reduced markers of oxidative damage, but only NAC significantly improved antioxidant levels and reduced harmful substances in ovarian tissue.
Article Abstract
This study evaluated the effects of N-acetylcysteine (NAC) and enoxaparin on ovarian tissue preservation, ovarian reserve and oxidative damage following ovarian torsion/detorsion injury. Rats were divided into four groups (n = 6/group): control; ischaemia/reperfusion (I/R); I/R + NAC; I/R + enoxaparin. Twenty-four hours after detorsion, ovarian tissues were collected for histopathological analysis and measurement of tissue 8-OHdG, GSH, MDA, MPO and SOD concentrations, as well as pre- and post-operative circulating AMH concentrations. Administration of NAC resulted in more pre-antral follicles compared with enoxaparin treatment and haemorrhage and follicle cell degeneration were more pronounced in I/R + enoxaparin group than I/R + NAC group. Both NAC and enoxaparin led to a significant reduction in ovarian tissue 8-OHdG (P = 0.004 and P = 0.01, respectively) and MPO (P = 0.013 and P = 0.023, respectively) concentrations compared with I/R group, indicating a protective effect against I/R oxidative damage. Only NAC-treated animals showed a significant increase in GSH and SOD concentrations and decrease in MDA concentrations compared with I/R group (P = 0.007, P = 0.024 and P = 0.026, respectively). These results indicate that NAC is more effective than enoxaparin in minimizing ovarian damage and preserving ovarian reserve following ovarian torsion.
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| http://dx.doi.org/10.1016/j.rbmo.2016.03.009 | DOI Listing |
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