AI Article Synopsis
- TEMPO-oxidized Konjac glucomannan (OKGM) was created as a new vegetarian option for hard capsules, tested at various oxidation levels (DO30%, DO50%, DO80%) to determine the best for capsule formation.
- FT-IR and XRD analyses showed that oxidation converted primary alcohols to carboxyl groups and reduced KGM's crystallinity, with DO80% proving optimal due to improved solubility, transparency, and reduced viscosity.
- DO80% OKGM capsules exhibited enhanced film properties, such as increased hydrophilicity and tensile strength, with a drug release profile indicating shell rupture in 5-10 minutes and 80% drug release in 30-
Article Abstract
TEMPO-oxidized Konjac glucomannan (OKGM) was developed as new material for preparing vegetarian hard capsules. OKGM of different degrees of oxidation: DO30%, DO50%, and DO80% were prepared to select optimum DO for capsule formation. FT-IR results proved that the primary alcohol groups on KGM were oxidized into carboxyl groups. XRD analysis suggested that TEMPO-oxidation decreased the crystallinity of KGM. DO80% was considered as the optimum candidate for capsule preparation owing to its superior solubility, transparency and reduced viscosity. The hydrophilicity of OKGM films, measured by contact angle measurement, increased with increasing DO. The elongation at break and tensile strength of the OKGM films enhanced with increasing DO. In vitro drug dissolution profile of OKGM capsules showed that the shell rupture time of DO80% capsule is about 5-10 min, and 80% of the drugs were released within 30-45 min. Thus DO80% OKGM was qualified to be used for gastric soluble hard capsules.
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| http://dx.doi.org/10.1016/j.carbpol.2016.01.072 | DOI Listing |
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