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Response of mucinous breast carcinoma to neoadjuvant chemotherapy.
Turk J Med Sci
December 2024
Department of Surgery, Division of General Surgery, Faculty of Medicine, İstanbul University, İstanbul, Turkiye.
Background/aim: Mucinous breast carcinoma (MBC) is thought to be a favorable-differentiated form of invasive breast cancer and is rarely preferred for neoadjuvant chemotherapy (NAC). The study aimed to define the response of MBCs to NAC.
Materials And Methods: A review was made of the demographic, clinicopathologic characteristics, management and follow-up data of 70 patients diagnosed with MBC between May 2010 and December 2020 by examining the patients' historical files and oncology records.
Lateralization-specific adaptation in auditory cortical evoked potentials: Comparison with frequency-specificity.
Eur J Neurosci
December 2024
Science Academy, Istanbul, Türkiye.
'Opponent channels model' (OCM) is the widely accepted model for cortical representation of sound lateralization. Stimulus-specific 'release from adaptation' (RFA) in cortical responses has been used in previous studies to test the predictions of this model. However, these attempts were shown to be prone to confounds of spurious responses such as those to auditory motion and sound onset.
View Article and Find Full Text PDFFractalkine/CX3CL1 and macrophage inflammatory protein- 1β/CCL4 activity in the rat ovary with induced ovarian hyperstimulation.
Turk J Obstet Gynecol
December 2024
Fırat University Faculty of Medicine, Department of Biochemistry, Elazığ, Turkey.
Objective: Fractalkine (CX3CL1) and macrophage inflammatory protein-1β (MIP-1β)/CCL4 play a role in chemotactic activity, immune response, and inflammatory response. We aimed to investigate the effects of fractalkine and MIP-1β in the development of ovarian hyperstimulation syndrome (OHSS) by considering the inflammatory response during ovulation.
Materials And Methods: Two equal groups of 20 immature female rats were created.
Oral biofluid levels of Activin-A and interleukin-1beta in stage III periodontitis.
Clin Oral Investig
December 2024
Department of Periodontology, Faculty of Dentistry, İstinye University, İstanbul, Turkey.
Objectives: Activin-A belongs to the transforming growth factor-beta superfamily and is a multifunctional cytokine that plays a role in inflammation, immune response, tissue repair and regeneration. Proinflammatory cytokine interleukin-1beta (IL-1β) can increase Activin-A expression in various cell types. This study aims to evaluate gingival crevicular fluid (GCF) and salivary Activin-A and IL-β levels in stage III periodontitis.
View Article and Find Full Text PDFEvaluation of Breast Cancer Gene Type 1 (BRCA1) Protein Levels in Cancer Tissue Using Surface-Enhanced Raman Spectroscopy.
Appl Spectrosc
December 2024
Faculty of Pharmacy, Department of Biochemistry, Gazi University, Ankara, Türkiye.
Article Synopsis
- - Raman spectroscopy is an advanced technique used to analyze the properties of matter, making it valuable for research, especially in cancer studies, where it helps understand gene and protein changes linked to tumor aggressiveness.
- - In breast cancer research, the study focused on the BRCA1 gene, which is challenging to measure using traditional methods due to its size, and employed surface-enhanced Raman spectroscopy (SERS) for precise protein quantification.
- - The research utilized magnetic nanoparticles to isolate the target protein and created a calibration curve that correlated Raman intensity with BRCA1 concentration, enabling accurate determination of protein levels in tissue samples.
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