Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1164/rccm.201512-2319ED | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Matriptase drives dissemination of ovarian cancer spheroids by a PAR-2/PI3K/Akt/MMP9 signaling axis.
J Cell Biol
November 2023
Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD, USA.
The transmembrane serine protease matriptase is a key regulator of both barrier-disruptive and protective epithelial cell-cell interactions. Elevated matriptase is a consistent feature of epithelial ovarian cancers (OvCa), where multicellular spheroids shed from the primary tumor into the peritoneal cavity are critical drivers of metastasis. Dynamic cell-to-cell adhesive contacts are required for spheroid formation and maintenance.
View Article and Find Full Text PDFThe roles of proteases in prostate cancer.
IUBMB Life
June 2023
Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Article Synopsis
- * Key proteases like KLK3 (PSA) and TMPRSS2 play significant roles in promoting prostate cancer and have been the focus of extensive research.
- * Recent studies indicate that proteases are also important in advanced castration-resistant prostate cancer (CRPC), highlighting the involvement of proteins like Notch and CDCP1 in its progression.
Downregulation of Matriptase Inhibits Porphyromonas gingivalis Lipopolysaccharide-Induced Matrix Metalloproteinase-1 and Proinflammatory Cytokines by Suppressing the TLR4/NF-B Signaling Pathways in Human Gingival Fibroblasts.
Biomed Res Int
October 2022
Department of Oral Biochemistry, And Institute of Biomaterials-Implant, College of Dentistry, Wonkwang University, Iksan City, Jeonbuk 54538, Republic of Korea.
Matriptases are cell surface proteolytic enzymes belonging to the type II transmembrane serine protease family that mediate inflammatory skin disorders and cancer progression. Matriptases may affect the development of periodontitis via protease-activated receptor-2 activity. However, the cellular mechanism by which matriptases are involved in periodontitis is unknown.
View Article and Find Full Text PDFThe activation fragment of PAR2 is elevated in serum from patients with rheumatoid arthritis and reduced in response to anti-IL6R treatment.
Sci Rep
December 2021
Nordic Bioscience, Immunoscience, Biomarkers and Research, Herlev, Denmark.
Osteoarthritis (OA) and rheumatoid arthritis (RA) are serious and painful diseases. Protease-activated receptor 2 (PAR2) is involved in the pathology of both OA and RA including roles in synovial hyperplasia, cartilage destruction, osteophyogenesis and pain. PAR2 is activated via cleavage of its N-terminus by serine proteases.
View Article and Find Full Text PDFDownregulation of matriptase suppresses the PAR‑2/PLCγ2/PKC‑mediated invasion and migration abilities of MCF‑7 breast cancer cells.
Oncol Rep
December 2021
Department of Oral Biochemistry, School of Dentistry, Wonkwang University, Iksan, Jeollabuk 570‑749, Republic of Korea.
Matriptases, members of the type II transmembrane serine protease family, are cell surface proteolytic enzymes that mediate tumor invasion and metastasis. Matriptase is highly expressed in breast cancer and is associated with poor patient outcome. However, the cellular mechanism by which matriptase mediates breast cancer invasion remains unknown.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!