Spontaneous Raman scattering is a powerful tool for chemical sensing and imaging but suffers from a weak signal. In this Letter, we present an application of adaptive optics to enhance the Raman scattering signal detected through a turbid, optically thick material. This technique utilizes recent advances in wavefront shaping techniques for focusing light through a turbid media and applies them to chemical detection to achieve a signal enhancement with little sacrifice to the overall simplicity of the experimental setup. With this technique, we demonstrate an enhancement in the Raman signal from titanium dioxide particles through a highly scattering material. This technique may pave the way to label-free tracking using the optical memory effect.

Download full-text PDF

Source
http://dx.doi.org/10.1364/OL.41.001769DOI Listing

Publication Analysis

Top Keywords

raman scattering
12
wavefront shaping
8
material technique
8
shaping enhanced
4
raman
4
enhanced raman
4
scattering
4
scattering turbid
4
turbid medium
4
medium spontaneous
4

Similar Publications

Surface-enhanced Raman scattering (SERS) technology has attracted more and more attention due to its high sensitivity, low water interference, and quick measurement. Constructing high-performance SERS substrates with high sensitivity, uniformity and reproducibility is of great importance to put the SERS technology into practical application. In this paper, we report a simple fabrication process to construct dense silver-coated PMMA nanoparticles-on-a-mirror SRES substrates.

View Article and Find Full Text PDF

Raman scattering of water in vicinity of polar complexes: Computational insight into baseline subtraction.

Spectrochim Acta A Mol Biomol Spectrosc

December 2024

Institute of Organic Chemistry and Biochemistry, Academy of Sciences, Flemingovo náměstí 2, 16610, Prague, Czech Republic; Department of Analytical Chemistry, University of Chemistry and Technology, Technická 5, 16628 Prague, Czech Republic. Electronic address:

Water is a greatly convenient solvent in Raman spectroscopy. However, non-additive effects sometimes make its signal difficult to subtract. To understand these effects, spectra for clusters of model ions, including transition metal complexes and water molecules, were simulated and analyzed.

View Article and Find Full Text PDF

Nanoscale surface topography is an effective approach in modulating cell-material interactions, significantly impacting cellular and nuclear morphologies, as well as their functionality. However, the adaptive changes in cellular metabolism induced by the mechanical and geometrical microenvironment of the nanotopography remain poorly understood. In this study, we investigated the metabolic activities in cells cultured on engineered nanopillar substrates by using a label-free multimodal optical imaging platform.

View Article and Find Full Text PDF

Estimating baselines of Raman spectra based on transformer and manually annotated data.

Spectrochim Acta A Mol Biomol Spectrosc

December 2024

Department of Agricultural Technology, Center for Precision Agriculture, Norwegian Institute of Bioeconomy Research (NIBIO), Nylinna 226 2849, Kapp, Norway.

Raman spectroscopy is a powerful and non-invasive analytical method for determining the chemical composition and molecular structure of a wide range of materials, including complex biological tissues. However, the captured signals typically suffer from interferences manifested as noise and baseline, which need to be removed for successful data analysis. Effective baseline correction is critical in quantitative analysis, as it may impact peak signature derivation.

View Article and Find Full Text PDF

The proliferation of micro/nanoplastics (MNPs) has emerged as a pivotal environmental issue, largely due to their potential for human exposure. Consequently, the development of sensitive and efficient detection methodologies is paramount for elucidating their environmental footprint. Here, we report a novel three-dimensional (3D) surface-enhanced Raman scattering (SERS) sensor, which integrate TiCT/TiO/WO semiconductor heterostructure, for the rapid and sensitive detection of MNPs in environmental matrices.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!