The synthesis of impurities detected in clandestinely manufactured Amphetamine Type Stimulants (ATS) has emerged as more desirable than simple "fingerprint" profiling. We have been investigating the impurities formed when phenyl-2-propanone (P2P) 5, a key ATS precursor, is synthesised in three steps; an aldol condensation of benzaldehyde and methyl ethyl ketone (MEK); a Baeyer-Villiger reaction; and ester hydrolysis. We have identified and selectively synthesised several impurities that may be used as route specific markers for this series of synthetic steps. Specifically these impurities are 3-methyl-4-phenyl-3-buten-2-one 3, 2-methyl-1,5-diphenylpenta-1,4-diene-3-one 9, 2-(methylamino)-3-methyl-4-phenyl-3-butene 16, 2-(Methylamino)-3-methyl-4-phenylbutane 17, and 1-(methylamino)-2-methyl-1,5-diphenylpenta-4-ene-3-one 22.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.forsciint.2016.03.034 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Oviposition-deterrent activity of p-methyl benzaldehyde and 2-hydroxy-5-methoxybenzaldehyde from the extract of Periplocae cortex for the control of Spodoptera frugiperda.
Pest Manag Sci
January 2025
Key Laboratory of Integrated Pest Management on Crops in Central China, Ministry of Agriculture and Rural Affairs, Hubei Key Laboratory of Crop Disease, Insect Pests and Weeds Control, Institute of Plant Protection and Soil Science, Hubei Academy of Agricultural Sciences, Wuhan, China.
Background: The invasion of Spodoptera frugiperda into China has caused serious losses to the food industry and has developed varying degrees of resistance to various chemical pesticides. Developing new plant-based pesticides is of great significance for the sustainable management of S. frugiperda.
View Article and Find Full Text PDFRuthenium-Hydride Complexes Facilitated Sustainable Synthesis of Isoxazolones via Acceptorless Dehydrogenative Annulation of Alcohols.
J Org Chem
January 2025
Centre for Organometallic Chemistry, School of Chemistry, Bharathidasan University, Tiruchirappalli 620 024, India.
A streamlined strategy for the one-pot synthesis of isoxazolone analogues has been developed through an acceptorless dehydrogenative annulation (ADA) pathway by employing new Ru(II) hydride complexes as effective catalysts. New Ru(II) complexes () tailored with N̂O chelating carbazolone benzhydrazone ligands were synthesized and their formation was confirmed using analytical and spectral techniques including FT-IR and NMR. The structural configuration of the complexes featuring an octahedral geometry around the Ru(II) ion was precisely determined by single-crystal X-ray diffraction analysis.
View Article and Find Full Text PDFCharacterization of the aromatic profile of Ruché wine from Piedmont (Italy) with gas chromatography-mass spectrometry and unsupervised machine learning techniques.
J Sci Food Agric
December 2024
Department of Chemistry, University of Turin, Turin, Italy.
Background: The volatile composition of Ruché, a red wine produced from a native grape in Piedmont (Italy), was investigated using headspace-solid phase microextraction (SPME) coupled to gas chromatography-mass spectrometry (GC/MS). The main volatile compounds of the wine were identified and quantified. Chemometric techniques were applied to identify features and possible clusters among the different samples.
View Article and Find Full Text PDFReactivity Study of the Bis(phosphine)-Stabilized Antimony(I) Cation.
Inorg Chem
December 2024
Department of Chemistry, Indian Institute of Science Education and Research, Pune, Dr. Homi Bhabha Road, Pashan, Pune 411008 Maharashtra, India.
The 5,6-Bis(diisopropylphosphino)acenaphthene -stabilized Sb(I) cationic compound [LSb][OTf] (OTf = CFSO) possessing two lone pairs of electrons on the Sb(I) center showed nucleophilic behavior toward methyl trifluoromethanesulfonate forming the oxidized product [LSbMe][OTf] (OTf = CFSO). Reaction of compound with Lewis acids such as GaCl and AlBr led to changes in the counteranions only giving products [LSb][GaCl] and [LSb][SbBr] , respectively. A metathesis reaction was observed when compound was reacted with PI.
View Article and Find Full Text PDFStructure-activity relationships between nitrile analogues and acaricidal activities against Haemaphysalis longicornis.
Pest Manag Sci
December 2024
Department of Pharmacy Practice, College of Pharmacy, University of Illinois, Champaign, IL, USA.
Background: A recent increase in severe fever with thrombocytopaenia syndrome (SFTS) virus cases in Korea has been observed. This virus attacks humans and animals, and no drug is available for its treatment. This study is investigating potential control measures targeting the causative agent, Haemaphysalis longicornis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!