Seventeen radar mechanics and engineers and 12 unexposed referents were examined, using extensive neurological, psychometric and neuropsychiatric techniques to determine whether there were any indications of central nervous system effects of microwave exposure. Pathological neurological findings were not more common in the exposed group than among the referents. In addition, the psychometric tests and the psychiatric rating scales did not reveal any statistically significant adverse effects of microwave exposure. The frequency of the occurrence of an increased protein band with an isoelectric point of 4.5 in the cerebrospinal fluid was higher among the men exposed to microwaves than among the referents. The nature and clinical significance of this or these proteins are still unclear. The time derivative of the magnetic flux density close to some of the transmitter units was surprisingly high (up to 350 T s-1).
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http://dx.doi.org/10.1097/00004032-198905000-00027 | DOI Listing |
J Kidney Cancer VHL
December 2024
Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Central nervous system hemangioblastoma (CNS-HB) is the most common manifestation of von Hippel-Lindau disease (VHL). The main axis of the CNS-HB pathway is the VHL-HIF signaling pathway. Recently, we proposed an alternative VHL-JAK-STAT pathway in CNS-HB.
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January 2025
Key Laboratory of Tropical Translational Medicine and Ministry of Education, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, China.
Axon guidance is a key event in neural circuit development that drives the correct targeting of axons to their targets through long distances and unique patterns. Exosomes, extracellular vesicles that are smaller than 100 nm, are secreted by most cell types in the brain. Regulation of cell-cell communication, neuroregeneration, and synapse formation by exosomes have been extensively studied.
View Article and Find Full Text PDFBMJ Neurol Open
January 2025
Siriraj Neuroimmunology Center, Division of Neurology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Salaya, Thailand.
Objective: This study aimed to elucidate the clinical manifestations, laboratory findings and outcomes of patients with intravascular large B cell lymphoma (IVLBCL) with neurological involvement and to differentiate IVLBCL with and without neurological involvement.
Methods: A cohort study was conducted at Siriraj Hospital, Mahidol University, Thailand, between January 2005 and September 2024. Clinical data, laboratory values and central nervous system imaging results were analysed.
NMC Case Rep J
December 2024
Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Hiroshima, Japan.
Older patients represent a unique and vulnerable subgroup, requiring careful consideration when determining treatment options. Treatment-related leukoencephalopathy is commonly observed in older patients months to years after receiving radiotherapy and/or methotrexate for primary central nervous system lymphoma (PCNSL). Tirabrutinib is an orally available, highly selective, and potent second-generation Bruton's tyrosine kinase inhibitor (BTKi) approved for treating recurrent/refractory PCNSL in Japan.
View Article and Find Full Text PDFFront Neurol
January 2025
Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun, China.
Retinal ganglion cells (RGCs) generally fail to regenerate axons, resulting in irreversible vision loss after optic nerve injury. While many studies have shown that modulating specific genes can enhance RGCs survival and promote optic nerve regeneration, inducing long-distance axon regeneration through single-gene manipulation remains challenging. Nevertheless, combined multi-gene therapies have proven effective in significantly enhancing axonal regeneration.
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