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HTL/KAI2 signaling substitutes for light to control plant germination.
PLoS Genet
October 2024
Department of Cell & Systems Biology, University of Toronto, Toronto, Canada.
Plants monitor multiple environmental cues, such as light and temperature, to ensure they germinate at the right time and place. Some specialist plants, like ephemeral fire-following weeds and root parasitic plants, germinate primarily in response to small molecules found in specific environments. Although these species come from distinct clades, they use the same HYPOSENSITIVE TO LIGHT/KARRIKIN INSENSITIVE 2 (HTL/KAI2) signaling pathway, to perceive different small molecules suggesting convergent evolution on this pathway.
View Article and Find Full Text PDFEukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge.
Nat Commun
July 2024
Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Proteos, Singapore, Republic of Singapore.
G-quadruplexes (G4s) formed by guanine-rich nucleic acids induce genome instability through impeding DNA replication fork progression. G4s are stable DNA structures, the unfolding of which require the functions of DNA helicases. Pif1 helicase binds preferentially to G4 DNA and plays multiple roles in maintaining genome stability, but the mechanism by which Pif1 unfolds G4s is poorly understood.
View Article and Find Full Text PDFAlternative translation initiation by ribosomal leaky scanning produces multiple isoforms of the Pif1 helicase.
Nucleic Acids Res
July 2024
Department of Biochemistry and Molecular Biology, CIMUS, Universidade de Santiago de Compostela-Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, A Coruña 15782, Spain.
In budding yeast, the integrity of both the nuclear and mitochondrial genomes relies on dual-targeted isoforms of the conserved Pif1 helicase, generated by alternative translation initiation (ATI) of PIF1 mRNA from two consecutive AUG codons flanking a mitochondrial targeting signal. Here, we demonstrate that ribosomal leaky scanning is the specific ATI mechanism that produces not only these, but also novel, previously uncharacterized Pif1 isoforms. Both in-frame, downstream AUGs as well as near-cognate start codons contribute to the generation of these alternative isoforms.
View Article and Find Full Text PDFMolecular mechanism of radiation tolerance in lung adenocarcinoma cells using single-cell RNA sequencing.
J Cell Mol Med
May 2024
Department of Respiration, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, China.
The efficacy of radiotherapy, a cornerstone in the treatment of lung adenocarcinoma (LUAD), is profoundly undermined by radiotolerance. This resistance not only poses a significant clinical challenge but also compromises patient survival rates. Therefore, it is important to explore this mechanism for the treatment of LUAD.
View Article and Find Full Text PDFIdentification of a prognosis-related gene signature and ceRNA regulatory networks in lung adenocarcinoma.
Heliyon
April 2024
In-Patient Ultrasound Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
Article Synopsis
- * A systematic bioinformatics analysis identified a signature of 12 specific genes within this network that negatively correlates with patient outcomes in lung adenocarcinoma.
- * Further verification through lab experiments confirmed the importance of the ceRNA regulatory network and highlighted the PIF1 and has-miR-125a-5p axis as significant in understanding lung adenocarcinoma mechanisms.
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