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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831792 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0154054 | PLOS |
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Detection of Patient-Level Immunotherapy-Related Adverse Events (irAEs) from Clinical Narratives of Electronic Health Records: A High-Sensitivity Artificial Intelligence Model.
Pragmat Obs Res
December 2024
Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Purpose: We developed an artificial intelligence (AI) model to detect immunotherapy -related adverse events (irAEs) from clinical narratives of electronic health records (EHRs) at the patient level.
Patients And Methods: Training data, used for internal validation of the AI model, comprised 1230 clinical notes from 30 patients at The Ohio State University James Cancer Hospital-20 patients who experienced irAEs and ten who did not. 3256 clinical notes of 50 patients were utilized for external validation of the AI model.
Visualizing Patient Pathways and Identifying Data Repositories in a UK Neurosciences Center: Exploratory Study.
JMIR Med Inform
December 2024
Lancaster Medical School, Lancaster University, Bailrigg, Lancaster, LA1 4YW, United Kingdom, 44 01524 594547.
Background: Health and clinical activity data are a vital resource for research, improving patient care and service efficiency. Health care data are inherently complex, and their acquisition, storage, retrieval, and subsequent analysis require a thorough understanding of the clinical pathways underpinning such data. Better use of health care data could lead to improvements in patient care and service delivery.
View Article and Find Full Text PDFAcute pyelonephritis in adults. Should we adopt the pediatric guidelines?
Urologia
December 2024
Department of Urology & Pediatric Urology, Shaare Zedek Medical Center, Faculty of Medical Science, Hebrew University, Jerusalem, Israel.
Purpose: There are no guidelines, what recommend pro or against cystography for identification of VUR for adults who suffer from first episode of pyelonephritis. The aim of this study was to look at incidence of VUR in adults with first episode of pyelonephritis, and to highlight recommendations for possible reflux investigation in these patients.
Methods: We have performed retrospective review of all patients who admitted at our department over the last decade with the working diagnosis of acute pyelonephritis.
Early results indicate that de-O-acetylated sialic acids increase Selectin binding in cancers.
Front Oncol
December 2024
Department of Chemistry, Biochemistry and Physics, South Dakota State University, Brookings, SD, United States.
Cancers utilize a simple glycan, Sialic Acid, to engage in metastatic processes via the Sialic acid (Sia) -Selectin pathway. Selectins recognize and bind to sialylated substrates, resulting in adhesion, migration, and extravasation, however, how deviations from the canonical form of Sia regulate binding to Selectin receptors (E, L, and P) on hemopoietic cells resulting in these metastatic processes, remained a gap in knowledge. De-O-acetylated Sias has been recently shown to be an integral substrate to the binding of sialic acid binding proteins.
View Article and Find Full Text PDFDiscrimination of leaf diseases in Maize/Soybean intercropping system based on hyperspectral imaging.
Front Plant Sci
December 2024
College of Agronomy, College of Mechanical and Electronic Engineering, Shandong Agricultural University, Taian, Shandong, China.
In order to achieve precise discrimination of leaf diseases in the Maize/Soybean intercropping system, i.e. leaf spot disease, rust disease, mixed leaf diseases, this study utilized hyperspectral imaging and deep learning algorithms for the classification of diseased leaves of maize and soybean.
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