AI Article Synopsis
- ALS is a serious disease that affects the nerve cells that control muscles, leading to weakness and problems moving.
- Researchers found a gene called CHCHD10 that causes ALS in some Western people, but when they looked at 294 Chinese patients, they didn't find any mutations in that gene.
- This suggests that the CHCHD10 gene might not be a common cause of ALS in Chinese individuals.
Article Abstract
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by the death of motor neurons. Recently, mutations in CHCHD10 have been reported to cause ALS in Western populations. In the present study, direct DNA sequencing has been performed on CHCHD10 in a cohort of 294 ALS patients of Chinese Han origin. No mutations were identified in CHCHD10 in ALS cases of Chinese ancestry. We propose CHCHD10 might not be a frequent causal gene among Chinese with ALS.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/21678421.2016.1170151 | DOI Listing |
Publication Analysis
Top Keywords
chchd10 frequent
8
gene chinese
8
chinese als
8
als patients
8
als
6
chchd10
5
frequent causative
4
causative gene
4
chinese
4
patients amyotrophic
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!