AI Article Synopsis

  • Resveratrol (RSV) is a compound that may help with metabolic diseases like diabetes and obesity by affecting brown adipose tissue (BAT), which is important for energy expenditure.
  • In studies with rats, RSV increased mitochondrial activity and estrogen receptor α (ER-α) in brown fat cells, especially when they were on a high-fat diet, and also increased the overall weight and differentiation of BAT.
  • RSV treatment improved insulin sensitivity in rats by enhancing mitochondrial function in BAT, suggesting it has potential benefits for metabolic health that warrant further research.

Article Abstract

Background: Resveratrol (RSV) is a polyphenolic phytoalexin that has many effects on metabolic diseases such as diabetes and obesity. Given the importance of brown adipose tissue (BAT) for energy expenditure, we investigated the effects of RSV on brown adipocytes.

Methods: For the in vitro study, interscapular BAT was isolated from 7-week-old male Sprague Dawley rats. For the in vivo study, 7-week-old male Otsuka Long Evans Tokushima Fatty (OLETF) rats were divided into four groups and treated for 27 weeks with: standard diet (SD); SD+RSV (10 mg/kg body weight, daily); high fat diet (HFD); HFD+RSV. RSV was provided via oral gavage once daily during the in vivo experiments.

Results: RSV treatment of primary cultured brown preadipocytes promoted mitochondrial activity, along with over-expression of estrogen receptor α (ER-α). In OLETF rats, both HFD and RSV treatment increased the weight of BAT and the differentiation of BAT. However, only RSV increased the mitochondrial activity and ER-α expression of BAT in the HFD-fed group. Finally, RSV improved the insulin sensitivity of OLETF rats by increasing the mitochondrial activity of BAT, despite having no effects on white adipocytes and muscles in either diet group.

Conclusion: RSV could improve insulin resistance, which might be associated with mitochondrial activity of brown adipocyte. Further studies evaluating the activity of RSV for both the differentiation and mitochondrial activity of BAT could be helpful in investigating the effects of RSV on metabolic parameters.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923418PMC
http://dx.doi.org/10.3803/EnM.2016.31.2.328DOI Listing

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