Background: National Institute for Health and Care Excellence guidelines used to triage patients with head injury to CT imaging are based on research conducted in populations presenting within 24 h of injury.We aim to compare guideline use, and outcomes, in patients with head injury that undergo CT imaging presenting within, and after 24 h of injury.
Methods: ED trauma CT head scan requests over a period of 6 months were matched to ED records. Case note review of adult patients with head injury that had undergone CT imaging was completed. Logistic regression was used to assess whether presentation after 24 h affected the guideline's ability to predict significant injuries.
Results: 650 case records were available for analysis. 8.6% (56/650) showed a traumatic abnormality, 1.5% (10/650) required neurosurgery or died. 15.5% (101/650) of CT scans were for patients presenting after 24 h. 8.4% (46/549) of those presenting within, and 9.9% (10/101) of those presenting after 24 h had traumatic CT abnormalities.The sensitivity of the guidelines for intracranial injuries was 98% (95% CI 87.0% to 99.9%) in those presenting within 24 h and 70% (95% CI 35.4% to 91.9%) in those presenting after 24 h of injury. The presence of a guideline indication statistically predicted significant injury, and this was unaffected by time of presentation.
Conclusions: Patients with head injury presenting after 24 h of injury are a clinically significant population. Existing guidelines appear to predict traumatic CT abnormalities irrespective of timing of presentation. However, their sole use in patients presenting after 24 h may result in significant injuries not being identified.
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http://dx.doi.org/10.1136/emermed-2015-205370 | DOI Listing |
Angew Chem Int Ed Engl
January 2025
Henan University of Technology, School of Chemistry and Chemical Engineering, CHINA.
Developing of molecular crystalline materials with light-induced multiple dynamic deformation in space dimension and photochromism on time scales has attracted much attention for its potential applications in actuators, sensoring and information storage. Nevertheless, organic crystals capable of both photoinduced dynamic effects and static color change are rare, particularly for multi-component cocrystals system. In this study, we first report the construction of charge transfer co-crystals allows their light-induced solid-to-liquid transition and photochromic behaviors to be controlled by trans-stilbene (TSB) as an electron donor and 3,4,5,6-Tetrafluorophthalonitrile (TFP) as an electron acceptor.
View Article and Find Full Text PDFPhysiol Plant
January 2025
Laboratory of Biochemistry, Institut Químic de Sarrià, Universitat Ramon Llull, Barcelona, Spain.
Photosynthetic microalgae are promising green cell factories for the sustainable production of high-value chemicals and biopharmaceuticals. The chloroplast organelle is being developed as a chassis for synthetic biology as it contains its own genome (the plastome) and some interesting advantages, such as high recombinant protein titers and a diverse and dynamic metabolism. However, chloroplast engineering is currently hampered by the lack of standardized cloning tools and Design-Build-Test-Learn workflows to ease genomic and metabolic engineering.
View Article and Find Full Text PDFPharmazie
December 2024
Drug Safety Center, Medical Faculty, Leipzig University and Leipzig University Hospital, Germany.
: Interprofessional education of medical and pharmacy students may improve competence-based university teaching. : We developed a joint bed-side teaching to improve patient-related competencies in identifying drug-related problems in hospitalized patients at a university cardiology department. Students were randomly allocated in mixed teams of medical and pharmacy students (1:3).
View Article and Find Full Text PDFAnn Surg Oncol
January 2025
Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan.
Background: Tumor size (TS) in pancreatic ductal adenocarcinoma (PDAC) is one of the most important prognostic factors. However, discrepancies between TS on preoperative images (TSi) and pathological specimens (TSp) have been reported. This study aims to evaluate the factors associated with the differences between TSi and TSp.
View Article and Find Full Text PDFAnat Sci Int
January 2025
Department of Anatomy, The Nippon Dental University School of Life Dentistry at Niigata, Niigata, Japan.
This case report presents an atypical transverse cervical artery with its detailed anatomy, morphogenesis, and association with the high arch-shaped subclavian artery. The atypical arteries, related arteries, and adjacent cervical and brachial plexuses were macroscopically examined in a 98-year-old Japanese female cadaver donated to The Nippon Dental University for medical education and research. The atypical deep branch of the transverse cervical artery originated from the internal thoracic artery and passed through between the C5 and C6 roots, in close contact with the C5 and C6 junction, to reach the dorsal side of the brachial plexus.
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