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A tunable and reversible thermo-inducible bio-switch for streptomycetes.
Nucleic Acids Res
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College of Agronomy and Biotechnology, Southwest University, No.2, Tiansheng Road, Beibei District, Chongqing 400715, China.
Programmable control of bacterial gene expression holds great significance for both applied and academic research. This is particularly true for Streptomyces, a genus of Gram-positive bacteria and major producers of prodigious natural products. Despite that a few inducible regulatory systems have been developed for use in Streptomyces, there is an increasing pursuit to augment the toolkit of high-performance induction systems.
View Article and Find Full Text PDFRevolutionizing Cardiac Care: The Role of Gene Therapy in Treating Cardiomyopathy.
Cardiol Rev
October 2024
Departments of Cardiology and Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY.
Gene therapy presents a method for addressing types of cardiomyopathies that play a substantial role in heart failure. This innovative approach, leveraging technologies such as clustered regularly interspaced short palindromic repeats/Cas9 for modifying genomes, holds promise for lasting treatments or potential cures that go beyond therapies. It is essential to grasp the workings of gene therapy, including gene silencing, clustered regularly interspaced short palindromic repeats genome editing, and enhancing sarcomere function to effectively apply it to treating cardiomyopathy.
View Article and Find Full Text PDFAdvances in Targeted Therapy: Addressing Resistance to BTK Inhibition in B-Cell Lymphoid Malignancies.
Cancers (Basel)
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Division of Hematology, Department of Medicine, University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA.
B-cell lymphoid malignancies are a heterogeneous group of hematologic cancers, where Bruton's tyrosine kinase (BTK) inhibitors have received FDA approval for several subtypes. The first-in-class covalent BTK inhibitor, Ibrutinib, binds to the C481 amino acid residue to block the BTK enzyme and prevent the downstream signaling. Resistance to covalent BTK inhibitors (BTKi) can occur through mutations at the BTK binding site (C481S) but also other BTK sites and the phospholipase C gamma 2 (PLCγ2) resulting in downstream signaling.
View Article and Find Full Text PDFGrapevine gray mold disease: infection, defense and management.
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Co-Innovation Center for Sustainable Forestry in Southern China, Department of Forest Protection, College of Forestry and Grassland, Nanjing Forestry University, Nanjing 210073, China.
Grapevine ( L.,) is among the world's leading fruit crops. The production of grapes is severely affected by many diseases including gray mold, caused by the necrotrophic fungus .
View Article and Find Full Text PDFRobust genome and cell engineering via in vitro and in situ circularized RNAs.
Nat Biomed Eng
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Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Circularization can improve RNA persistence, yet simple and scalable approaches to achieve this are lacking. Here we report two methods that facilitate the pursuit of circular RNAs (cRNAs): cRNAs developed via in vitro circularization using group II introns, and cRNAs developed via in-cell circularization by the ubiquitously expressed RtcB protein. We also report simple purification protocols that enable high cRNA yields (40-75%) while maintaining low immune responses.
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