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CFATransUnet: Channel-wise cross fusion attention and transformer for 2D medical image segmentation.
Comput Biol Med
January 2024
Department of Optical Science and Engineering, Fudan University, Shanghai 200433, China; Academy for Engineering and Technology, Fudan University, Shanghai 200433, China; Zhuhai Fudan Innovation Institute, Zhuhai 519031, China. Electronic address:
Medical image segmentation faces current challenges in effectively extracting and fusing long-distance and local semantic information, as well as mitigating or eliminating semantic gaps during the encoding and decoding process. To alleviate the above two problems, we propose a new U-shaped network structure, called CFATransUnet, with Transformer and CNN blocks as the backbone network, equipped with Channel-wise Cross Fusion Attention and Transformer (CCFAT) module, containing Channel-wise Cross Fusion Transformer (CCFT) and Channel-wise Cross Fusion Attention (CCFA). Specifically, we use a Transformer and CNN blocks to construct the encoder and decoder for adequate extraction and fusion of long-range and local semantic features.
View Article and Find Full Text PDFUnnexin is a protein subunit of a large-pore channel expressed by unicellular organisms.
Proc Natl Acad Sci U S A
August 2023
Laboratory of Gap Junction Proteins and Parasitic Diseases (GaPaL), Instituto Antofagasta, Universidad de Antofagasta, Antofagasta 1240000, Chile.
Cells of vertebrate and invertebrate organisms express proteins specialized in membrane channel-based cell-cell communication that are absent in unicellular organisms. We recently described the prediction of some members of the large-pore channel family in kinetoplastids, consisting of proteins called unnexins, which share several structural features with innexin and pannexin proteins. Here, we demonstrated that the unnexin1 protein (Unx1) is delivered to the cell membrane, displaying a topology consisting of four transmembrane domains with C and N termini on the cytoplasmic side and form large-pore channels that are permeable to small molecules.
View Article and Find Full Text PDFFrom non-excitable single-cell to multicellular bioelectrical states supported by ion channels and gap junction proteins: Electrical potentials as distributed controllers.
Prog Biophys Mol Biol
December 2019
Dept. Termodinàmica, Universitat de València, E-46100, Burjassot, Spain.
Endogenous bioelectric patterns within tissues are an important driver of morphogenesis and a tractable component of a number of disease states. Developing system-level understanding of the dynamics by which non-neural bioelectric circuits regulate complex downstream cascades is a key step towards both, an evolutionary understanding of ion channel genes, and novel strategies in regenerative medicine. An important capability gap is deriving rational modulation strategies targeting individual cells' bioelectric states to achieve global (tissue- or organ-level) outcomes.
View Article and Find Full Text PDFChannel-Based Gap Mapping for Pulmonary Vein Isolation.
J Cardiovasc Electrophysiol
April 2016
Department of Electrophysiology, Heart Center, Leipzig, Leipzig, Germany.
The dual face of connexin-based astroglial Ca(2+) communication: a key player in brain physiology and a prime target in pathology.
Biochim Biophys Acta
October 2014
Department of Basic Medical Sciences, Physiology group, Faculty of Medicine and Health Sciences, Ghent University, B-9000 Ghent, Belgium.
For decades, studies have been focusing on the neuronal abnormalities that accompany neurodegenerative disorders. Yet, glial cells are emerging as important players in numerous neurological diseases. Astrocytes, the main type of glia in the central nervous system , form extensive networks that physically and functionally connect neuronal synapses with cerebral blood vessels.
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