Background: We examined whether or not extended prophylaxis with low molecular weight heparin (LMWH) would significantly reduce thromboembolic event (TEE) rates in germ cell cancer patients undergoing cisplatin-based chemotherapy.
Patients And Methods: LMWH prophylaxis was given from the first day of chemotherapy until 21 days after completing the last chemotherapy cycle to 45 out of 93 (48.4%) patients (extended), and to 48 out of 93 (51.6%) patients during their hospitalization only (limited) between January 2008 and December 2013. Patients were analyzed retrospectively for TEEs such as deep vein thrombosis (DVT), pulmonary embolism (PE), myocardial infarction (MI) or peripheral arterial thrombosis.
Results: A total of 22/93 (23.7%) patients experienced 30 TEE during chemotherapy: 12 out of 30 (40%) deep vein thrombosis, 4 out of 30 (13.3%) MI, 10 out of 30 (33.3%) PE and 4 out of 30 peripheral arterial thrombosis (13.3%). TEE rates in both groups did not differ significantly (extended: 26.7 vs. limited: 20.8%).
Conclusions: The introduction of extended LMWH prophylaxis did not significantly reduce TEE rates in our patient cohort.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000445126 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Virus adaptation to heparan sulfate comes with capsid stability tradeoff.
Elife
December 2024
Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland.
Because of high mutation rates, viruses constantly adapt to new environments. When propagated in cell lines, certain viruses acquire positively charged amino acids on their surface proteins, enabling them to utilize negatively charged heparan sulfate (HS) as an attachment receptor. In this study, we used enterovirus A71 (EV-A71) as the model and demonstrated that, unlike the parental MP4 variant, the cell-adapted strong HS-binder MP4-97R/167 G does not require acidification for uncoating and releases its genome in the neutral or weakly acidic environment of early endosomes.
View Article and Find Full Text PDFCOVID-19 Increases the Risk of New Myocardial Infarction in Patients with Old Myocardial Infarction: A Retrospective Observational Study.
Clin Med Insights Cardiol
December 2024
Trauma Surgery Section, Hamad Medical Corporation, Doha, Qatar.
Background: We aimed to investigate the incidence of new acute myocardial infarction (AMI), in patients with Coronavirus disease (COVID-19) who had old MI. We hypothesized that COVID-19 increases the rate of repeated AMI in this population regardless of age and gender.
Methods: A retrospective analysis was conducted for adult patients admitted with COVID-19 and developed thromboembolic event (TEE) in 2020.
Presence of patent foramen ovale does not increase cerebrovascular event rates in patients with atrial fibrillation following left atrial appendage closure.
Heliyon
November 2024
Department of Cardiology, Wuhan Asia Heart Hospital, Wuhan, Hubei Province, 430022, China.
Article Synopsis
- The study investigates the relationship between atrial fibrillation (AF) and patent foramen ovale (PFO) regarding the risk of ischemic stroke, focusing on whether closing PFO is necessary for stroke prevention in AF patients undergoing left atrial appendage closure (LAAC).
- Researchers analyzed clinical data from 614 patients who underwent LAAC to compare outcomes between AF patients with PFO and those without, particularly looking at ischemic stroke rates and major adverse cardiovascular events (MACEs).
- The findings indicate that there is no significant difference in stroke rates or MACEs between patients with and without PFO, suggesting that PFO closure may not be necessary for stroke prevention in AF patients after LAAC.
Safety and Clinical Outcomes of a Complete "Minimalist" Left Atrial Appendage Occlusion Pathway.
Catheter Cardiovasc Interv
December 2024
Department of Medicine, Division of Cardiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
The standard approach to catheter based left atrial appendage occlusion (LAAO) involves trans-esophageal echocardiography (TEE) guided screening and placement, and procedural general anesthesia requiring overnight stay. In pursuit of improved patient experience and reduced cost, streamlined approaches in each phase of care have been explored. However, the safety and clinical outcomes for a completely protocolized minimalist approach utilizing computed tomography angiogram (CTA), intracardiac echocardiography (ICE), conscious sedation, and same-day discharge are lacking.
View Article and Find Full Text PDFIncomplete cor triatriatum dexter and percutaneous closure of atrial septal defects, a single-centre experience.
Acta Cardiol
November 2024
Interventional Cardiology Unit, Miguel Servet University Hospital, Zaragoza, Spain.
Article Synopsis
- Cor Triatriatum Dexter (CTD) is a rare heart defect that splits the right atrium into two chambers, with a milder version called incomplete CTD (CTDi) that only partially divides it.
- CTDi can be linked to interatrial septal defects and often presents in adults who experience cryptogenic strokes, usually leading to referrals for closure of a patent foramen ovale (PFO).
- Successful PFO closure in patients with CTDi can be challenging due to complications in visualization and device deployment, making advanced imaging techniques and careful planning essential for positive outcomes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!