2,6-Bis(benzimidazol-2-yl)pyridine as a potent transmembrane anion transporter.

Bioorg Med Chem Lett

Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China.

Published: May 2016

2,6-Bis(benzimidazol-2-yl)pyridine was shown to exhibit potent anionophoric activity via a process of both Cl(-)/NO3(-) antiport and H(+)/Cl(-) symport. This is in sharp contrast to the finding that its corresponding N-methylated analog exhibited negligible activity and reveals the importance of the imidazolyl-NH fragments in the anion-transport process.

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http://dx.doi.org/10.1016/j.bmcl.2016.03.114DOI Listing

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