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Successful Multi-Modal Laser Intervention and Histopathological Evaluation of Multiple Glomangiomas.
Lasers Surg Med
December 2024
Department of Dermatology, Veterans Health Administration, San Antonio, Texas, USA.
Objectives: Glomangiomas are benign vascular malformations that exist within the spectrum of glomuvenous malformations which consist of varying amounts of glomus cells, vascular spaces, and smooth muscle. Glomangiomas are often treated due to associated pain, particularly when located on pressure areas such as the back or extensor surfaces, which can cause difficulty with certain activities and occupational functions. Histologically glomangiomas consist of prominent dilated vascular spaces lined by glomus cells typically situated in the deep-dermis to subcutaneous fat which limits treatment to modalities capable of reaching the depth of the tumor including excision, sclerotherapy, and laser therapy.
View Article and Find Full Text PDFReceptor tyrosine kinase inhibition leads to regression of acral melanoma by targeting the tumor microenvironment.
J Exp Clin Cancer Res
December 2024
The Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Background: Acral melanoma (AM) is an aggressive melanoma variant that arises from palmar, plantar, and nail unit melanocytes. Compared to non-acral cutaneous melanoma (CM), AM is biologically distinct, has an equal incidence across genetic ancestries, typically presents in advanced stage disease, is less responsive to therapy, and has an overall worse prognosis.
Methods: An independent analysis of published sequencing data was performed to evaluate the frequency of receptor tyrosine kinase (RTK) ligands and adapter protein gene variants and expression.
Tinea Nigra: Clinical and Diagnostic Guidance.
Cureus
August 2024
Medical Benefits, Mexican Social Security Institute, Campeche, MEX.
Article Synopsis
- - Tinea nigra is a rare fungal infection that mainly affects the palms and soles, presenting as painless dark spots, which can be mistaken for other skin lesions.
- - A case study of a 64-year-old woman from Yucatan, Mexico, diagnosed with tinea nigra through skin scrapings showed pigmented yeast, leading to successful treatment with topical ketoconazole.
- - The report emphasizes the importance of thorough examinations and a proposed diagnostic algorithm to improve recognition and treatment of tinea nigra, particularly in areas where it is less common.
Receptor tyrosine kinase inhibition leads to regression of acral melanoma by targeting the tumor microenvironment.
bioRxiv
June 2024
The Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Acral melanoma (AM) is an aggressive melanoma variant that arises from palmar, plantar, and nail unit melanocytes. Compared to non-acral cutaneous melanoma (CM), AM is biologically distinct, has an equal incidence across genetic ancestries, typically presents in advanced stage disease, is less responsive to therapy, and has an overall worse prognosis. Independent analysis of published genomic and transcriptomic sequencing identified that receptor tyrosine kinase (RTK) ligands and adapter proteins are frequently amplified, translocated, and/or overexpressed in AM.
View Article and Find Full Text PDFPattern Analysis of Benign and Malignant Atypical Melanocytic Skin Lesions of Palms and Soles: Variations of Dermoscopic Features According to Anatomic Site and Personal Experience.
Life (Basel)
May 2024
Dermatology Unit, Department of Medical, Surgical and Neurosciences, University of Siena, 53100 Siena, Italy.
Article Synopsis
- * Researchers collected a dataset of 471 lesions from 10 European centers and evaluated them through a blinded analysis involving 156 dermatologists of varying experience, using a specialized online platform.
- * The findings revealed that certain areas, like the heel and fingers, had higher rates of early-stage melanomas compared to atypical nevi, and demonstrated that diagnosing lesions in the plantar arch was particularly challenging for dermatologists.
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