Eight standardbred horses trotted on a treadmill for 55 mins at a sub-maximal speed of 5m/sec and subsequently performed an exercise test consisting of 2 min intervals at increasing speed. Heart (HR) and respiratory (Rf) rates and venous blood samples were obtained before, during and for 5 mins after exercise. Gluteus medius muscle biopsies and rectal temperatures were taken before and after exercise. The mean HR was 132/min and the mean Rf was 156/min during the 5m/sec trotting. With 5m/sec exercise, plasma free fatty acids (FFA), glucose, creatinine and cortisol concentrations increased markedly. Blood lactate increased slightly and plasma potassium increased initially and then decreased with a lengthened duration of trotting. Within 5 mins post exercise plasma FFA, glucose and cortisol concentrations continued to rise, whereas creatinine and lactate levels declined slightly and potassium concentrations declined rapidly to below resting values. The mean intramuscular (im) glycogen utilisation was 86 mmol/kg, no significant changes occurred in creatine phosphate (CP), adenosine triphosphate (ATP) and glucose-6-phosphate (G-6-P) concentrations and muscle lactate decreased significantly. During the second exercise test mean HR was 215/min and Rf 126/min at top speed. No significant change was seen in plasma glucose whereas cortisol levels rose to a lesser extent, and creatinine lactate, ammonia and potassium concentrations to a greater extent, compared to 5 m/sec trotting. Post exercise, these parameters continued to increase except for creatinine which declined slightly and potassium which decreased rapidly. The mean im glycogen utilisation was 144 mmol/kg, ATP concentrations were unaltered, CP declined, lactate and G-6-P increased during exercise.(ABSTRACT TRUNCATED AT 250 WORDS)
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Sci Rep
January 2025
Department of Sport Games, Józef Piłsudski University of Physical Education in Warsaw, Marymoncka 34, Warsaw, 00-968, Poland.
This study aimed to examine and compare the anthropometric profiles, motor skills, game-related abilities, and functional capacities of under-15 (U-15) and under-16 (U-16) male basketball players, evaluate the impact of maturity offset, and predict performance across physical and sport-specific domains. A total of 234 athletes participated in a comprehensive test battery, assessing morphological (height, mass, standing reach), physical (sprinting, agility, jump height, endurance), technical (jump shot, free throws, dribbling), and functional movement screen variables. The U-16 group outperformed U-15 players in physical characteristics and jump height.
View Article and Find Full Text PDFVet Clin North Am Equine Pract
January 2025
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA. Electronic address:
Myofibrillar myopathy (MFM) is characterized by segmental disarray of myofibrils and ectopic accumulation of a protein called desmin. Previously thought to be a glycogen storage disease, MFM is now recognized as a stand-alone myopathy. Endurance Arabians with MFM usually present with exertional rhabdomyolysis (MFM-ER) at the end of races, elevated serum muscle enzymes, and myoglobinuria.
View Article and Find Full Text PDFThorax
January 2025
Genome Medicine Laboratory, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal
Objective: Reduced functional capacity and muscle weakness are two major contributors to functional impairment in chronic obstructive pulmonary disease (COPD). The underlying causes of functional impairment are poorly understood and, therefore, we sought to investigate the contribution of genetic factors.
Methods: We conducted a cross-sectional analysis of sociodemographic, clinical and genetic information of people with COPD.
BMJ Open
January 2025
University of Social Welfare and Rehabilitation Science, Tehran, Iran (the Islamic Republic of).
Objective: To investigate how various morbidities affect older patients' performance on the Timed Up and Go (TUG) test.
Design: Cross-sectional study.
Setting: The seven government hospitals of Lahore, Pakistan, included are major tertiary care centres, representing an older patient population of Punjab, Pakistan.
BMJ Open
January 2025
Department of Cardiovascular Sciences, University of Leicester and the National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester LE3 9QP, UK
Introduction: Heart failure with preserved ejection fraction (HFpEF) is characterised by severe exercise intolerance, particularly in those living with obesity. Low-energy meal-replacement plans (MRPs) have shown significant weight loss and potential cardiac remodelling benefits. This pragmatic randomised trial aims to evaluate the efficacy of MRP-directed weight loss on exercise intolerance, symptoms, quality of life and cardiovascular remodelling in a multiethnic cohort with obesity and HFpEF.
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