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Background: Eclampsia is among the primary causes of maternal and perinatal morbidity and mortality in Zanzibar. Many women and men are not aware of the signs, symptoms and causes of eclampsia and may have different explanatory models. Therefore, this study aimed to describe the community understanding of pre-eclampsia, as a key stage to improve maternal and perinatal health in Unguja Island, Zanzibar.
View Article and Find Full Text PDFAnalysis of healthcare utilization before the diagnosis of radiologically isolated syndrome.
Mult Scler
January 2025
Rennes University, EHESP, CNRS, Inserm, ARENES UMR 6051, RSMS U 1309, Rennes, France.
Background: Previous studies have shown that people with multiple sclerosis (MS) had frequent healthcare visits up to 10 years before being diagnosed but with no information from magnetic resonance imaging (MRI) scans of the connection with the radiologically isolated syndrome (RIS).
Objective: To analyze healthcare use 3 years before the RIS diagnosis.
Methods: We examined healthcare usage before the first scan in RIS cases from 2010 to 2019.
LINE-1, the NORth star of nucleolar organization.
Genes Dev
January 2025
Institute for Research on Cancer and Aging of Nice (IRCAN), Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), University Cote d'Azur, Nice 06107, France
Long interspersed element-1 (LINE-1) retrotransposons are abundant transposable elements in mammals and significantly influence chromosome structure, chromatin organization, and 3D genome architecture. In this issue of , Ataei et al. (doi:10.
View Article and Find Full Text PDFBarriers to Yearly Diabetic Retinopathy Screening Attendance: A Retrospective Clinical Audit.
Cureus
December 2024
Ophthalmology, Calderdale Royal Hospital, Halifax, GBR.
Diabetic retinopathy is the most common sight-threatening complication of diabetes, necessitating regular monitoring of progression via diabetic eye screening (DES). The National Institute for Health and Care Excellence (NICE) recommends DES annually for diabetic patients aged 12 years and older. This retrospective clinical audit assessed the reasons behind non-attendance and evaluated the adherence to guidelines set by NICE in a general practice with approximately 9000 patients.
View Article and Find Full Text PDFHow are patient inputs considered in HTA? A thematic document analysis of NICE ultra-rare disease appraisals.
Eur J Health Econ
December 2024
Department of Health Policy, London School of Economics and Political Science, Houghton street, London, WC2A 2AE, UK.
Patient organisations are increasingly involved in HTA. Given this, it is important to understand what these organisations contribute and how their voices are accounted for in the decision-making process. This study characterises inputs from patient organisations and/or their nominated patient experts in technology appraisals for ultra-rare diseases in England and Wales and seeks to understand how these are considered in NICE final recommendations.
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