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Analysis of antibody dynamics in Chinese children aged 1-3 years after single-dose varicella vaccination: A 42 months prospective study.
Hum Vaccin Immunother
December 2024
Department of Rheumatology and Immunology, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian, Jiangsu, China.
In China, children aged 12 months receive only a single dose of the varicella vaccine and the incidence of varicella remains high. This study aims to evaluate the changes in immunity among children aged 1-3 years following a single dose of the varicella vaccine, providing a scientific basis for determining the optimal age for a second vaccination. This prospective cohort study employed glycoprotein enzyme-linked immunosorbent assay (gpELISA) for antibody detection.
View Article and Find Full Text PDFVaricella vaccine effectiveness evaluation in Wuxi, China: A retrospective cohort study.
Epidemiol Infect
September 2024
The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University, Wuxi Center for Disease Control and Prevention, Wuxi, China.
Article Synopsis
- * A study involving 382,397 children from 2012 to 2016 showed that while breakthrough varicella cases initially increased, the overall incidence of the disease significantly decreased as vaccination rates rose, peaking in the fifth year.
- * The vaccine effectiveness was notably high, ranging from 88.17%-95.78% for one dose to 98.65%-99.93% for two doses, indicating strong support for a two-dose vaccination strategy to improve
A population database analysis to estimate the varicella vaccine effectiveness in children < 14 years in a high vaccination coverage area from 2004 to 2022.
Vaccine
December 2024
Department of Cardiac Thoracic and Vascular Sciences and Public Health, University of Padua, 35131, Padua, Italy.
Introduction: In the Veneto Region of Italy, universal varicella vaccination (VV) started in 2007 with a two-dose schedule at 12-15 months and 5-6 years of age achieving 90 % coverage in 2019. The study aimed at evaluating the vaccine effectiveness (VE) in children using a primary-care database METHODS: This retrospective analysis used Pedianet, a comprehensive database of 73 family paediatricians in the Veneto Region. Incidence rates (IR) of varicella were evaluated in children aged <14 years enrolled since birth, between January 2004 to April 2022.
View Article and Find Full Text PDFHelicase-primase inhibitors for the treatment of herpes simplex virus infections - patent evaluation of WO2023/225162 from Gilead Sciences Inc.
Expert Opin Ther Pat
October 2024
Innovative Molecules GmbH, München, Germany.
Helicase-primase is an interesting target for small-molecule therapy of herpes simplex virus (HSV) infections. With amenamevir already approved for varicella-zoster virus and herpes simplex in Japan and with 's granted breakthrough therapy designation for the treatment of acyclovir-resistant HSV infections in immunocompromised patients, the target has sparked interest in helicase-primase inhibitors (HPIs). Here, we analyze the first patent application from Gilead in this field, which pursued a me-too approach combining elements from an old Bayer together with a recent Medshine HPI application (which covers the Phaeno Therapeutics drug candidate ).
View Article and Find Full Text PDFDiurnal rhythms in varicella vaccine effectiveness.
JCI Insight
September 2024
Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel.
BACKGROUNDImmune processes are influenced by circadian rhythms. We evaluate the association between varicella vaccine administration time of day and vaccine effectiveness.METHODSA national cohort, children younger than 6 years, were enrolled between January 2002 and December 2023.
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