AI Article Synopsis
- 15-30% of AIDS patients do not regain normal CD4(+) T cell levels after antiretroviral therapy, even when HIV-1 replication is successfully suppressed.
- The study investigated 65 adult AIDS patients with controlled viral loads to explore reasons for immune recovery failure, focusing on HLA alleles.
- Findings showed that carriers of HLA-A68 and HLA-B15 had significantly higher proportions of poor immune responses, with potential etiological contributions of 57.89% and 61.35%, respectively.
Article Abstract
Around 15-30% of AIDS patients fail to recover their CD4(+) T cell levels following combined antiretroviral therapy despite successful inhibition of HIV-1 replication. The exact reasons for this immune recovery failure are not completely understood. HLA alleles are among the candidate that may explain this failure. A total of 65 adult AIDS patients, with viral load of <50 copies per ml were investigated. Viral load and CD4 T cells counts were performed following standard techniques. HLA genotyping was performed using PCR-SSP technique. The Statistical Package for Social Sciences (SPSS version 19) was used for data processing and analysis. A significantly higher proportion of poor immune responders were carrying HLA-A68 (4.8% compared to 25.0%, P=0.025) and HLA-B15 (2.4% compared to 20.8%, P=0.023). The etiological fraction (Efe%) among carriers of HLA-A68 was 57.89% (95% CI=26.79, 75.79) and was 61.35% (95% CI=35.33, 76.91) among carriers of HLA-B15.
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| http://dx.doi.org/10.1016/j.humimm.2016.04.009 | DOI Listing |
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