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Initial Assessment of the Molecular Epidemiology of blaNDM-1 in Colombia. | LitMetric
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Initial Assessment of the Molecular Epidemiology of blaNDM-1 in Colombia.

Laura J Rojas Meredith S Wright Elsa De La Cadena Gabriel Motoa Kristine M Hujer Maria V Villegas Mark D Adams Robert A Bonomo

Antimicrob Agents Chemother

Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA

Published: July 2016

We report complete genome sequences of four blaNDM-1-harboring Gram-negative multidrug-resistant (MDR) isolates from Colombia. The blaNDM-1 genes were located on 193-kb Inc FIA, 178-kb Inc A/C2, and 47-kb (unknown Inc type) plasmids. Multilocus sequence typing (MLST) revealed that these isolates belong to sequence type 10 (ST10) (Escherichia coli), ST392 (Klebsiella pneumoniae), and ST322 and ST464 (Acinetobacter baumannii and Acinetobacter nosocomialis, respectively). Our analysis identified that the Inc A/C2 plasmid in E. coli contained a novel complex transposon (Tn125 and Tn5393 with three copies of blaNDM-1) and a recombination "hot spot" for the acquisition of new resistance determinants.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914651PMC
http://dx.doi.org/10.1128/AAC.03072-15DOI Listing

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