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Follow-Up of Infants With Congenital Cytomegalovirus Following Maternal Primary Infection in the First Trimester and Normal Fetal Brain Imaging at Midgestation.
Prenat Diagn
December 2024
Obstetric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Objective: To determine outcomes at birth and postnatal sequelae of congenital cytomegalovirus (cCMV) infection following maternal primary infection in the first trimester with normal fetal brain imaging at midgestation.
Methods: A retrospective, single-center cohort study was conducted, including all cases of proven cCMV infection following maternal primary infection in the first trimester from 2014 until 2021 and normal fetal brain imaging before 22 weeks of gestation. All pregnancies were followed according to our protocol, which offers amniocentesis at least 8 weeks after the onset of infection, serial ultrasound scans, and a fetal MRI in the third trimester.
Cytomegalovirus (CMV) reactivation is a rare complication in patients treated with immune checkpoint inhibitors (ICIs), typically occurring after immunosuppressive therapy for immune-related adverse events (irAEs). Here, we report a unique case of severe CMV gastritis in a patient receiving cemiplimab, an anti-PD-1 antibody, and talimogene laherparepvec (T-VEC), an oncolytic virus, without prior irAEs or immunosuppressive treatment. A 63-year-old man with advanced cutaneous squamous cell carcinoma received cemiplimab for one year and a single T-VEC injection for recurrent disease.
View Article and Find Full Text PDFCutaneous Ulcers in an Individual with Acquired Immunodeficiency Syndrome: A Case Report.
J Assoc Physicians India
November 2024
Director and Chief Consultant, Department of Infectious diseases, Institute of Infectious Diseases; Consultant, Department of Internal Medicine, Poona Hospital and Research Centre, Pune, Maharashtra, India.
We report an unusual presentation of Cytomegalovirus (CMV) cutaneous perianal ulcerative lesion in a patient with severe immunosuppression. A 43-year-old male presented with perianal ulcer along with bleeding and pain while passing stools. On biopsy, the ulcer showed typical histopathological features of CMV infection with involvement of endothelial cells.
View Article and Find Full Text PDFArticle Synopsis
- Adenovirus infections are particularly dangerous for immunocompromised individuals, with no FDA-approved treatment currently available, leading to the off-label use of cidofovir which has kidney toxicity.
- Research has shown that USC-093, an orally administered prodrug, is effective against adenovirus in hamsters, showing less nephrotoxicity compared to traditional treatments.
- The study details the synthesis of USC-093 and its D-homoserinamide analogue, finding that both have significantly higher potency against adenoviruses compared to cidofovir, particularly highlighting the benefits of USC-093D in terms of efficacy.
Co-Infection of Cytomegalovirus and Leishmania without Splenomegaly Resulting in Immunosuppression in an Hiv-Negative Patient.
Eur J Case Rep Intern Med
October 2024
Department of Lab Sciences and Pathology, 167 Military Hospital, Pathankot, India.
Article Synopsis
- Leishmaniasis, transmitted by sand flies, is prevalent in Bihar, India, with three common forms: cutaneous, mucosal, and visceral, typically presenting as fever and enlarged organs.
- A case of pyrexia of unknown origin revealed a patient with low CD4 counts (HIV-negative) who was diagnosed with co-infection of CMV and visceral leishmaniasis, despite lacking typical signs like hepatosplenomegaly.
- Effective treatment with ganciclovir and amphotericin led to symptom resolution, highlighting the importance of recognizing rare presentations and co-infections in immunocompromised patients.
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