The authors describe the implantation of the Argus II Retinal Prosthesis System (Argus II) (Second Sight Medical Products, Sylmar, CA) into a short axial length (AL) eye. The authors' main modification is the use of endocyclophotocoagulation (endo-CPC) to the ciliary processes in the area that the cable enters through the sclerotomy. This case describes the surgical technique necessary for successful implantation of the Argus II into a short AL eye. The use of endo-PC prevents chafing to the ciliary processes, does not affect postoperative intraocular pressure, and facilitates direct visualization of the structures during the surgery, preventing damage during implantation.
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http://dx.doi.org/10.3928/23258160-20160324-12 | DOI Listing |
JACC Heart Fail
November 2024
Semmelweis University, Heart and Vascular Center, Budapest, Hungary. Electronic address:
Background: In the BUDAPEST (Biventricular Upgrade on left ventricular reverse remodeling and clinical outcomes in patients with left ventricular Dysfunction and intermittent or permanent APical/SepTal right ventricular pacing)-CRT Upgrade randomized trial, the authors have demonstrated improved mortality and morbidity after cardiac resynchronization therapy (CRT) upgrade in patients with heart failure with reduced ejection fraction (HFrEF) with high right ventricular (RV) pacing burden.
Objectives: This substudy sought to examine the impact of CRT upgrade on symptoms, functional outcome, and exercise capacity.
Methods: In the BUDAPEST-CRT Upgrade trial, 360 HFrEF patients with pacemaker or implantable cardioverter-defibrillator (ICD) and ≥20% RV pacing burden were randomly assigned (3:2) to cardiac resynchronization therapy with defibrillator (CRT-D) upgrade (n = 215) or ICD (n = 145).
Transl Vis Sci Technol
November 2024
Department of Psychological & Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA, USA.
Purpose: Visual prosthetics are a promising assistive technology for vision loss, yet research often overlooks the human aspects of this technology. While previous studies focus on the perceptual experiences or attitudes of implant recipients (implantees), a systematic account of how current implants are being used in everyday life is still lacking.
Methods: We interviewed six recipients of the most widely used visual implants (Argus II and Orion) and six leading researchers in the field.
Eur J Ophthalmol
October 2024
Uveitis and Scleritis Service, Moorfields Eye Hospital NHS Foundation Trust, London, UK.
Purpose: Avacopan is a novel C5a receptor inhibitor which was recently licensed for treatment of severe granulomatosis with polyangiitis (GPA) in the European Union and the United Kingdom. To the best of our knowledge, this is the first described case on initial ophthalmic outcomes in a patient with severe GPA and concurrent refractory scleritis treated with avacopan.
Case Description: We present a case of de novo scleritis in a 77-year-old male with a background of retinitis pigmentosa with Argus II implant in situ.
Eur Heart J Digit Health
September 2024
Heart and Vascular Centre, Semmelweis University, 68 Városmajor Street, 1122 Budapest, Hungary.
Aims: We aimed to externally validate the SEMMELWEIS-CRT score for predicting 1-year all-cause mortality in the European Cardiac Resynchronization Therapy (CRT) Survey I dataset-a large multi-centre cohort of patients undergoing CRT implantation.
Methods And Results: The SEMMELWEIS-CRT score is a machine learning-based tool trained for predicting all-cause mortality in patients undergoing CRT implantation. This tool demonstrated impressive performance during internal validation but has not yet been validated externally.
BMJ Open Ophthalmol
August 2024
Ophthalmology and Visual Neurosciences, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.
Objective: To quantitatively evaluate visual evoked potentials (VEPs) in prosthetic vision and simulated visual reduction.
Methods And Analysis: Four blind patients implanted with the Argus II retinal prosthesis and seven sighted controls participated. VEPs were recorded with pattern-reversal stimuli (2 cycles of a horizontal square wave grating, 0.
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