AI Article Synopsis
- Early signs of Multiple Sclerosis (MS) can often appear as psychiatric episodes, complicating diagnosis.
- Researchers contacted neurologists to identify MS patients who had psychiatric symptoms before or around the time of MS diagnosis.
- The study found that patients with earlier psychiatric episodes were diagnosed significantly later than those with neurological symptoms, raising questions about the relationship between these psychiatric manifestations and the onset of MS.
Article Abstract
Background: Early manifestations of Multiple Sclerosis (MS) can be atypical and misleading, and several case report studies have highlighted that MS onset sometimes takes the form of a psychotic or manic episode.
Methods: All neurologists belonging to the French Multiple Sclerosis Observatory network were contacted by email and were asked to find patients with MS who presented with a history of psychiatric episode(s) near MS onset.
Results: Seventeen patients were selected that met the criteria of presenting with psychotic or manic symptoms either before the diagnosis of MS (N=8), or at the time of the first neurological episode or shortly after (N=9). Patients with a history of a psychiatric episode occurring before the first neurological episode were diagnosed on average 7 years later than patients with either a first neurological or a mixed (both neurological and psychiatric) episode. However, psychiatric symptoms in the first group and the first neurological symptoms of MS in the second group occurred at a similar age.
Conclusion: Based on this multiple case study, we question whether past psychotic or manic episode should be considered equivalent to a first manifestation of MS.
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| http://dx.doi.org/10.1016/j.msard.2016.02.004 | DOI Listing |
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