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Trust in scientists and their role in society across 68 countries.
Nat Hum Behav
January 2025
Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, the Netherlands.
Science is crucial for evidence-based decision-making. Public trust in scientists can help decision makers act on the basis of the best available evidence, especially during crises. However, in recent years the epistemic authority of science has been challenged, causing concerns about low public trust in scientists.
View Article and Find Full Text PDFEffectiveness of patient education on the quality of life of patients with rheumatoid arthritis: A systematic review and meta-analysis.
Semin Arthritis Rheum
December 2024
Institute of Nursing and Health Sciences, Agadir, Morocco.
Background: Rheumatoid arthritis (RA) has a considerable negative impact on quality of life (QoL) and represents a significant burden on healthcare systems worldwide. Although patient education (PE) programs are advocated as an integral component of comprehensive RA management, the magnitude and sustainability of their QoL benefits remain unclear. This meta-analysis seeks to assess the efficacy of PE interventions in enhancing QoL among RA patients.
View Article and Find Full Text PDFQuantifying uncertainty of molecular mismatch introduced by mislabeled ancestry using haplotype-based HLA genotype imputation.
Front Genet
September 2024
PIRCHE AG, Berlin, Germany.
Article Synopsis
- Modern histocompatibility algorithms analyze high-resolution HLA protein sequences to enhance epitope-based models for antibody or T cell interactions, with genotype imputation improving accuracy, especially when considering an individual's ancestry.
- The study compares molecular matching scores from high-resolution genotypes to those derived from low-resolution imputed genotypes using both simulated and real datasets.
- Results show that multiple imputation leads to lower errors in matching scores, and proper ancestry assumptions can further improve accuracy, making imputation a useful method for epitope analysis when used thoughtfully.
The Role of Selection and Migration in the Evolution of (Auto)Immunity Genes.
J Mol Evol
August 2024
Department of Basic and Clinical Sciences, University of Nicosia Medical School, Nicosia, Cyprus.
The genetic architecture of multiple sclerosis is complicated. Additionally, the disease incidence varies per population or per geographical region. A recent study gives convincing explanations about the north-south incidence gradient of multiple sclerosis in Europe, by analyzing ancient and modern human genomes.
View Article and Find Full Text PDFThe 18th International HLA & Immunogenetics workshop project report: Creating fully representative MHC reference haplotypes.
HLA
June 2024
Department of Biomedical Informatics, University of Colorado School of Medicine, Aurora, Colorado, USA.
Article Synopsis
- * Currently, about 20% of the combined haplotypes from Europe are represented, but many common and rare haplotypes, particularly those associated with certain diseases, are still lacking from the global sample.
- * The workshop is now seeking DNA samples from diverse populations, especially non-Europeans, resulting in 537 individuals contributing 294 distinct haplotypes, but still highlighting the need for more representation, particularly from African populations.
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