Evaluation of cardiac function in unrestrained dogs and monkeys using left ventricular dP/dt.

J Pharmacol Toxicol Methods

Bristol Myers Squibb, 3553 Lawrenceville Rd, Princeton, NJ 08540, United States. Electronic address:

Published: May 2017

AI Article Synopsis

  • - The ICH S7b guidelines for cardiovascular safety studies have not emphasized preclinical assessments of cardiac ventricular function, although there is increasing interest due to potential cardiovascular risks linked to positive and negative inotropes.
  • - Between 2003 and 2013, Bristol Myers Squibb conducted 163 telemetry studies on cardiac function in dogs and monkeys, confirming their telemetry system's reliability with control agents, and evaluating the statistical significance of contractility changes.
  • - The studies revealed that certain drug candidates significantly affected cardiac contractility, with some causing changes related to heart rate or blood pressure. A new analysis tool was created to better identify these effects during drug development.

Article Abstract

Introduction: Preclinical assessment for alterations in cardiac ventricular function for drug candidates has not been a focus of ICH S7b guidelines for cardiovascular safety studies, but there is growing interest given that the cardiovascular risk is associated with positive and negative inotropes.

Methods: From 2003 through 2013, 163 telemetry studies with left-ventricular function analyses were conducted in dogs and monkeys at Bristol Myers Squibb (BMS) in support for drug development programs. The ability of the telemetry system to detect changes in cardiac contractility was verified with positive control agents pimobendan and atenolol. Control data from a subset of studies were analyzed to determine dP/dt reference range values, and minimum detectable mean differences (control vs. treated) for statistical significance.

Results: Median minimum detectable differences for dogs ranged from 14 to 21% for positive dP/dt and 11 to 21% for negative dP/dt. For monkeys, median minimum detectable differences were 25 and 14% for positive and negative dP/dt, respectively. For BMS programs, 15 drug candidates were identified that produced primary effects on contractility. Changes in contractility that were associated with, and potentially secondary to, drug-related effects on heart rate or systemic blood pressure were observed with an additional 29 drug candidates.

Discussion: Changes in contractility have been observed in large animals during drug development studies at BMS over the past 10years. Model sensitivity has been demonstrated and a dP/dt beat-to-beat cloud analysis tool has been developed to help distinguish primary effects from those potentially secondary to systemic hemodynamic changes.

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http://dx.doi.org/10.1016/j.vascn.2016.03.006DOI Listing

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