AI Article Synopsis
- Proanthocyanidins found in peanut skin have antibacterial properties, particularly against food-borne bacteria like Bacillus cereus.
- The peanut skin extract (PSE), especially the compound EEC, was more effective at inhibiting B. cereus than other compounds like procyanidin A1.
- DNA analysis showed that EEC disrupted B. cereus's cell membrane and metabolism, leading to significant changes in gene expression and inhibited glucose uptake.
Article Abstract
Proanthocyanidins are abundant in peanut skin, and in this study, the antibacterial effects of a peanut skin extract (PSE) against food-borne bacteria were investigated to find its minimum inhibitory concentration. Food-borne gram-positive bacteria, and in particular Bacillus cereus, was more sensitive to PSE. In particular, the inhibitory activity of epicatechin-(4β → 6)-epicatechin-(2β → O→7, 4β → 8)-catechin (EEC), a proanthocyanidin trimer from peanut skin, against B. cereus was stronger than that of procyanidin A1, a proanthocyanidin dimer. DNA microarray analysis of B. cereus treated with EEC was carried out, with a finding that 597 genes were significantly up-regulated. Analysis of the up-regulated genes suggested that EEC disrupted the normal condition of the cell membrane and wall of B. cereus and alter its usual nutritional metabolism. Moreover, treatment of B. cereus with EEC inhibited glucose uptake, suggesting that EEC affects the cell-surface adsorption.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899491 | PMC |
| http://dx.doi.org/10.1007/s00284-016-1032-x | DOI Listing |
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