Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.biopsych.2016.02.028 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
n-acetyl-l-cysteine stimulates bone healing by recovering the age-associated degenerative complications relative to osteoblastic Wntless ablation.
Biomed Pharmacother
January 2025
Department of Bioactive Material Sciences, Research Center of Bioactive Materials, Jeonbuk National University, Jeonju 54896, South Korea; Cluster for Craniofacial Development and Regeneration Research, Institute of Oral Biosciences, School of Dentistry, Jeonbuk National University, Jeonju 54896, South Korea. Electronic address:
Dysregulated Wnt signaling causes age-related characteristics such as oxidative stress, stem cell senescence, and abnormal bone homeostasis. Here we explored whether supplemental n-acetyl-l-cysteine (NAC) recovers the age-associated complications relative to osteoblastic Wntless (Wls) ablation and examined the possible mechanisms therein. For this work, we administered Col2.
View Article and Find Full Text PDFMitochondrial CLPB is a pro-survival factor at the onset of granulocytic differentiation of mouse myeloblastic cells.
Apoptosis
December 2024
Department of Biochemistry and Molecular Biophysics, Kansas State University, 141 Chalmers Hall, Manhattan, KS, 66506, USA.
Article Synopsis
- Loss-of-function mutations in the CLPB gene result in congenital neutropenia, impairing the differentiation of neutrophil precursor cells, though the underlying mechanism is unclear.
- In experiments using IL-3-dependent mouse myeloblastic 32Dcl3 cells, researchers found that CLPB knockout led to decreased mitochondrial membrane potential and increased HAX1 aggregates, but did not affect cell proliferation under IL-3.
- The increased apoptosis of CLPB-deficient cells after IL-3 withdrawal was linked to reactive oxygen species (ROS), with citrate supplementation showing potential to protect these cells by enhancing ROS detoxification through ATP-citrate lyase (ACLY) activity.
The impact of N-acetylcysteine on lactate, biomarkers of oxidative stress, immune response, and muscle damage: A systematic review and meta-analysis.
J Cell Mol Med
December 2024
Department of Human Nutrition and Dietetics, Poznań University of Life Sciences, Poznań, Poland.
Article Synopsis
- * A meta-analysis of 20 studies found that NAC significantly lowered muscle soreness, lactate levels, IL-6, and TBARS, while increasing GSH concentrations after physical activity.
- * No significant effects of NAC on TNF-α, creatine kinase (CK), or glutathione disulfide (GSSG) were observed, indicating its targeted benefits in recovery processes.
Therapeutic Potential of N-acetylcysteine and Glycine in Reducing Pulmonary Injury in Diabetic Rats.
Cureus
November 2024
Pathophysiology and Internal Medicine, University of Sarajevo, Sarajevo, BIH.
Introduction: Diabetes mellitus is associated with systemic complications, including the development of pulmonary injury, characterized mainly by excessive accumulation of extracellular matrix components and inflammatory cell infiltration in lung tissue. This process is driven by oxidative stress and chronic inflammation, both caused and exacerbated by hyperglycemia. N-acetylcysteine (NAC) and glycine, known for their antioxidant and anti-inflammatory effects, offer potential therapeutic benefits in mitigating diabetes-induced lung injury.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!