AI Article Synopsis
- The study investigates how miR-375 influences the differentiation of preadipocytes into adipose tissues using isolated porcine cells.
- miR-375 was found to act as a negative regulator of this process by targeting the bone morphogenetic protein receptor 2 (BMPR2).
- Silencing BMPR2 produced similar effects to increasing miR-375, confirming its role in inhibiting adipogenic differentiation.
Article Abstract
The differentiation of preadipocytes into adipose tissues is tightly regulated by various factors including miRNAs and cytokines. In this study, taking advantage of isolated porcine primary preadipocytes, we showed that ectopic expression of miR-375 could change preadipocyte differentiation. In addition, bone morphogenetic protein receptor 2 (BMPR2) was identified as a direct target of miR-375. Silencing BMPR2 had the same inhibition effects as overexpressing miR-375 on the preadipocyte differentiation. Together, we demonstrated that miR-375 is a negative regulator of adipogenic differentiation using porcine primary preadipocytes. These results clarified the role of miR-375 in ex vivo adipogenic differentiation.
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| http://dx.doi.org/10.1002/1873-3468.12169 | DOI Listing |
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