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The Bone-Vascular Axis: A Key Player in Chronic Kidney Disease Associated Vascular Calcification.
Kidney Dis (Basel)
December 2024
Department of Nephrology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Background: The bone-vascular axis plays a key role in the pathogenesis of vascular calcification (VC) in patients with chronic kidney disease (CKD). Understanding and managing the role of the bone-vascular axis in CKD-mineral and bone disorder (CKD-MBD) is critical for preventing and treating associated complications, including osteoporosis, arterial calcification, and cardiovascular diseases. This study aimed to comprehensively summarize the role of bone metabolism markers in uremic VC.
View Article and Find Full Text PDFGlycogen Storage Disease Type I and Bone: Clinical and Cellular Characterization.
Calcif Tissue Int
November 2024
Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio, Coppito 2, 67100, L'Aquila, Italy.
Glycogen storage disease (GSD) is the most prevalent inherited disorder of glycogen metabolism for which no causal treatment is available. In recent years, thanks to the improved clinical management, the life expectancy of these patients extended, disclosing previously unidentified adverse conditions in other organs. In this study, we evaluated the clinical bone complications and the cellular responses in 20 patients (aged 14.
View Article and Find Full Text PDFHigh-Intensity Interval Training, but Not Whole-Body Cryostimulation, Affects Bone-Mechanosensing Markers and Induces the Expression of Differentiation Markers in Osteoblasts Cultured with Sera from Overweight-to-Obese Subjects.
J Pers Med
September 2024
Laboratory of Experimental Biochemistry and Molecular Biology, IRCCS Ospedale Galeazzi-Sant'Ambrogio, 20157 Milano, Italy.
Although there have been some clinical observations made, the mechanistic effects on bone metabolism of whole-body cryostimulation and high-intensity interval training (HIIT), either alone or in combination, are still debated. Here, we have investigated their effects on circulating osteo-immune and bone metabolic markers (osteopontin, osteocalcin, sclerostin, dikkopf-related protein 1, and fibroblast-growth factor 23) and their potential effects on osteoblast differentiation and function, , by treating SaOS-2 osteoblast-like cells with the sera obtained from the subjects who had undergone the different interventions or untreated control subjects. Sixty-seven inactive, overweight-to-obese participants (body mass index = 31.
View Article and Find Full Text PDFElevated Circulating Sclerostin Levels in Frail Older Adults: Implications beyond Bone Health.
Endocrinol Metab (Seoul)
October 2024
Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Article Synopsis
- Sclerostin is primarily known for its role in bone health but this study investigates its potential link to frailty in older adults, highlighting its broader impact on health.* -
- Blood samples from 244 seniors were analyzed, revealing that higher sclerostin levels were significantly associated with increased frailty, as measured by two validated methods.* -
- The results suggest that sclerostin could serve as a valuable biomarker for assessing frailty, indicating a need for further research on its implications for the health of the elderly.*
ALK1 Signaling in Human Cardiac Progenitor Cells Promotes a Pro-angiogenic Secretome.
J Cell Signal
January 2024
Center for Molecular Medicine, MaineHealth Institute for Research, MaineHealth 81 Research Drive, Scarborough, Maine, USA.
Pro-angiogenic paracrine/autocrine signaling impacts myocardial repair in cell-based therapies. Activin A receptor-like type 1 (, ALK1) signaling plays a pivotal role in cardiovascular development and maintenance, but its importance in human-derived therapeutic cardiac cells is not well understood. Here, we isolated a subpopulation of human highly proliferative cells (hHiPCs) from adult epicardial tissue and found that they express ALK1, a high affinity receptor for bone morphogenetic protein-9 (BMP9), which signals via SMAD1/5 to regulate paracrine/autocrine signaling and angiogenesis.
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