Monoclonal antibodies (mAb) are central to the treatment of several types of malignancy. However, these reagents are subject to particular types of resistance. Several resistance mechanisms are regulated by the inhibitory FcγRIIB. We recently developed mAbs to block FcγRIIB and provided proof-of-concept for their ability to overcome FcγRIIB-mediated resistance.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801439 | PMC |
| http://dx.doi.org/10.1080/2162402X.2015.1069939 | DOI Listing |
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