AI Article Synopsis
- Oligodendrogliomas are rare infiltrative brain tumors, with genetic factors, specifically SNPs in MMP genes, potentially influencing their development and progression.
- This study investigated the connection between specific MMP gene polymorphisms (MMP-1, MMP-2, MMP-7) and oligodendroglioma risk using samples from affected individuals and healthy controls.
- Significant associations were found for MMP-1 and MMP-7 polymorphisms with increased oligodendroglioma susceptibility, while no significant link was established for MMP-2, indicating its limited role in this type of tumor.
Article Abstract
Background: Oligodendrogliomas are infiltrative astrocytic tumors. They constitute about 1-5% of intracranial tumors. These have been graded into benign and malignant grades. The single nucleotide polymorphisms (SNPs) in the promoter regions of MMP genes may influence tumor development and progression. This study was done to explore the correlations of the promoter SNPs in MMP-1, MMP-2 and MMP-7 genes susceptibility in development and progression of oligodendrogliomas.
Objectives: We aimed to investigate the association of MMP1 (-1607A > G), MMP-2 (-1306 C/T) and MMP-7(-181A > G) gene polymorphism in oligodendrogliomas (grade I, II, III).
Materials And Methods: In the present case control study, we enrolled a total of 30 cases of oligodendrogliomas (grade I to III) confirmed by histopathology and 30 healthy cases as control. Polymorphism for MMP-1 gene (-1607A > G), MMP-2 (-1306 C/T), MMP-7(-181A > G) were genotyped by restriction fragment length polymorphism.
Results: Frequencies of MMP-1 (-1607A > G) genotypes and 2G alleles were significantly associated with the cases of oligodendrogliomas (30%) in relation to healthy controls (13%). [OR = 6.89; P = 0.02; 95%CI= (1.33-35.62)] and [OR = 2.66; P =0.01; 95% CI= (1.26-5.64)]. A significant association of MMP-2 (-1306C/T) polymorphism with oligodendroglioma (P = 0.54) was not found, suggesting that MMP-2 (-1306C/T) polymorphism is not associated with increased oligodendroglioma susceptibility. Frequencies of MMP-7(-181A > G) genotypes and 2G alleles were significantly associated with the cases of oligodendrogliomas (33.33%) in relation to healthy controls (13.33%). [OR = 5.65; P = 0.02; 95%CI= (1.26-25.36)] and [OR = 2.49; P =0.01; 95% CI= (1.17-5.27)].
Conclusions: MMP-1 (-1607 A > G), MMP-7(-181A > G) genotypes and 2G alleles were significantly associated with oligodendroglioma (grade I, II, III), but MMP-2 (-1306C/T) polymorphism is not associated with increased oligodendroglioma susceptibility.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802938 | PMC |
| http://dx.doi.org/10.4103/1793-5482.145338 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Chromosomal gain and mutations of gene in canine high-grade oligodendroglioma.
Vet Pathol
January 2025
The University of Tokyo, Tokyo, Japan.
Canine high-grade oligodendrogliomas (HGOGs) exhibit a high expression of platelet-derived growth factor receptor-α (PDGFRA). We examined mutations and gain of and their association with the PDGFRA expression and proliferation of tumor cells in canine HGOG cases and cell lines. Polymerase chain reaction and sequence analysis revealed expected pathogenic mutations in exons 7 and 8 in 16/34 (47%) cases.
View Article and Find Full Text PDFAre Dinucleotide Alterations Definitional for Myxoid Glioneuronal Tumor? Report of p. K385L Mutation in a Neonatal High-Grade Glioma.
Pediatr Dev Pathol
December 2024
Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Tumors are increasingly defined by molecular alterations but approach to cases with discordant histologic and molecular features is unclear. Myxoid glioneuronal tumor (MGNT), histologically similar to dysembryoplastic neuroepithelial tumor (DNET), is characterized by dinucleotide mutations in gene (K385L or K385I). Here, we report K385L mutation in a neonatal high-grade glioma.
View Article and Find Full Text PDFDiffuse Glioneuronal Tumor With Oligodendroglioma-Like Features and Nuclear Clusters Relapse in a Seven-Year-Old Boy: An Unusual Case Exhibiting Near-Tetraploidy and Chromosome 14 Diploidy.
Cureus
November 2024
Hematology and Oncology, CHRISTUS Children's, Baylor College of Medicine, San Antonio, USA.
Diffuse glioneuronal tumor with oligodendroglioma-like features and nuclear clusters (DGONC) is a rare brain tumor of the central nervous system (CNS). Although only a few cases of DGONC have been reported following the initial description of the tumor, they have a distinct DNA methylation pattern and share a recurrent chromosomal finding of monosomy 14. We encountered a seven-year-old boy who presented with seizures and was found to have a left frontal and suprasellar mass.
View Article and Find Full Text PDFCongress of Neurological Surgeons systematic review and evidence-based guidelines for the role of chemotherapy in newly diagnosed WHO Grade II diffuse glioma in adults: update.
J Neurooncol
January 2025
Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA.
Article Synopsis
Glioma subtype prediction based on radiomics of tumor and peritumoral edema under automatic segmentation.
Sci Rep
November 2024
Department of Neurosurgery, Zhongnan Hospital of Wuhan University, No.125 Donghu Road, WuChang, Wuhan, 430062, China.
Comprehensive and non-invasive preoperative molecular diagnosis is important for prognostic and therapy decision-making in adult-type diffuse gliomas. We employed a deep learning method for automatic segmentation of brain gliomas directly from conventional magnetic resonance imaging (MRI) scans of the tumor core and peritumoral edema regions based on available glioma MRI data provided in the BraTS2021. Three-dimensional volumes of interest were segmented from 424 cases of glioma imaging data retrospectively obtained from two medical centers using the segmentation method and radiomic features were extracted.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!