Pemphigus vegetans is an autoimmune bullous disorder characterized by vegetating lesions commonly over the flexures. A 42-year-old female patient came with pemphigus vegetans presenting with interesting cerebriform morphology of the cutaneous lesions over the flexures. Cerebriform tongue, a morphology with typical pattern of sulci and gyri over dorsum of the tongue is a well-known sign seen in pemphigus vegetans. Interestingly, we noticed the typical sulci and gyri pattern in the skin lesions of pemphigus vegetans over the flexures of the body. This clinical sign can be used as a clue in the diagnosis of pemphigus vegetans. Morphology and physical characteristics are important for the diagnosis of the disease. Clinical signs always give a clue to the probable or possible diagnosis in most of the dermatological conditions.
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http://dx.doi.org/10.4103/0019-5154.177760 | DOI Listing |
Indian Dermatol Online J
July 2024
Department of Dermatology, SRIHER, Chennai, Tamil Nadu, India.
Int J Gynecol Pathol
August 2024
Department of Pathology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan.
Int J Dermatol
August 2024
Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
J Dermatol
December 2024
Department of Dermatology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.
Pemphigus vegetans is a rare type of pemphigus characterized by vegetative lesions primarily localized to the intertriginous area. Despite its unique clinical presentation, the underlying pathomechanism remains unclear owing to the rarity of the disease. We report a case of pemphigus vegetans with antibodies against desmoglein 1 and desmocollins 1-3.
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