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Similar Publications

Characterizing Protracted Febrile Myalgia: Fasciitis and Vasculitis of the Fascia and Muscle as Novel Histopathological Features.

J Clin Med

December 2024

Department of Internal Medicine, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, 08036 Barcelona, Spain.

: Protracted febrile myalgia (PFM) is a rare but severe form of myalgia mainly occurring in pediatric patients with familial Mediterranean fever (FMF). PFM imaging and histopathological data remain scarce. : A comprehensive clinical, imaging, and histopathological characterization of PFM was performed by retrospectively analyzing a reference center cohort of adult patients with FMF and myalgia, and by a PubMed search of well-described cases with PFM.

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Objective: The aim of this study was to identify key parameters of a scoring system to be developed to predict the homozygous M694V genotype in patients clinically diagnosed with familial Mediterranean fever.

Methods: This study was a cross-sectional analysis of 472 pediatric familial Mediterranean fever patients with a homozygous genotype on exon 10, followed at our tertiary pediatric rheumatology clinic between June 2016 and June 2023. The patients were categorized into 2 groups based on their genotypes: group 1 comprised 402 patients (85.

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Leeds Long COVID Community Rehabilitation Service, Leeds Community Healthcare NHS Trust, Leeds LS11 0DL, UK.

Article Synopsis
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Article Synopsis
  • Protracted febrile myalgia syndrome (PFMS) occurs in patients with familial Mediterranean fever and presents with symptoms like severe muscle pain, fever, and joint issues lasting weeks.
  • A study analyzed 17 PFMS cases from a pediatric clinic, revealing that most patients had a specific gene mutation and highlighting the challenge of diagnosing PFMS, especially since it can sometimes appear without fever.
  • Treatment typically includes nonsteroidal anti-inflammatory drugs and corticosteroids; however, some patients might need long-term therapy with anakinra or canakinumab to manage severe symptoms effectively.
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Introduction: Protracted febrile myalgia syndrome (PFMS) is a rare manifestation of familial Mediterranean fever (FMF), characterized by myalgia, fever and elevated inflammatory markers lasting several weeks. As the hallmark of FMF are short episodes of disease symptoms, the long duration of PFMS may lead to a delayed diagnosis and treatment.

Objectives: 1.

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