Medicinal Chemistry Research Laboratories, Ono Pharmaceutical Co., Ltd, 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan.
Published: May 2016
AI Article Synopsis
Article Abstract
The modification of the novel G protein-biased EP2 agonist 1 has been investigated to improve its G protein activity and develop a better understanding of its structure-functional selectivity relationship (SFSR). The optimization of the substituents on the phenyl ring of 1, followed by the inversion of the hydroxyl group on the cyclopentane moiety led to compound 9, which showed a 100-fold increase in its G protein activity compared with 1 without any increase in β-arrestin recruitment. Furthermore, SFSR studies revealed that the combination of meta and para substituents on the phenyl moiety was crucial to the functional selectivity.
The study examines how modified corn straw biochar impacts water-related soil properties by preparing biochar through pyrolysis and modifying it with specific solvents.
Various tests were conducted to analyze soil hydraulic conductivity, water evaporation, and moisture content using different concentrations and amounts of biochar.
Results indicated that adding modified biochar significantly reduced soil hydraulic conductivity, improved water retention, and affected evaporation rates, providing insights for enhancing soil water retention in arid regions.
Food Science, School of Chemical Sciences, The University of Auckland, Auckland 1010, New Zealand; Riddet Institute, Centre of Research Excellence in Food Research, Palmerston North 4474, New Zealand. Electronic address:
Hempseed protein isolate (HPI), a novel plant protein, possesses advantages as an alternative food protein from a nutritional and sustainable perspective. This study investigated HPI modification by examining the effects of high-pressure homogenization combined with high-intensity ultrasound (HPH + HIU) on the physicochemical and functionality of HPI. Firstly, the optimal homogenization pressure (180 MPa) was selected based on the solubility and particle size of HPI.
School of Materials Science and Engineering, and the Key Laboratory of Structure & Functional Regulation of Hybrid Materials, Ministry of Education, Anhui University, Hefei, 230601, P. R. China.
To achieve high selectivity in photocatalytic CO reduction to C products, increasing the number of CO adsorption sites and lowering the energy barriers for key intermediates are critical. A ZnInS (ZIS)/MoO (Z-M) photocatalyst is presented, in which plasmonic MoO generates hot electrons, creating a multielectron environment in ZIS that facilitates efficient C─C coupling reactions. Density functional theory (DFT) calculations reveal that MoO reduces the formation energy of sulfur vacancies (S) in ZIS, thereby enhancing CO adsorption and activation.
To address the delamination phenomenon during storage and flavor characteristics of Oyster protein hydrolysates (OPH). In this study, xylo-oligosaccharides (XOS) were selected to covalently graft with OPH through ultrasound-assisted Maillard reaction, and the effect of ultrasound-assisted Maillard reaction on the structure, functional properties, and flavor characteristics of OPH were investigated. The results revealed that the ultrasound treatment led to a 1.
- Faba bean starch (FBS) can be improved using dry heat treatment (DHT), which enhances its functional properties while being eco-friendly, and the study looked at how varying temperature (100-150 °C) and time (0.5-5 h) affect these attributes.
- The results showed that DHT increased viscosity measures like peak, final, and setback while decreasing amylose content, but did not change the starch's color, structure, or crystallinity significantly.
- The best DHT conditions for improving FBS were found to be 100 °C for about 0.1716 hours, achieving a desirability factor of 66%, making it more effective than corn starch in certain
