AI Article Synopsis
- - The article explores the role of PECAM-1, a molecule in endothelial cells, in keeping the vascular permeability barrier intact and helping it recover after being disrupted.
- - PECAM-1 is mainly found at the junctions between endothelial cells, where it helps maintain their integrity and aids in recovery during inflammation or clotting events.
- - Antibodies that interact with PECAM-1 could potentially be used to treat conditions related to vascular permeability due to their ability to enhance cell adhesion.
Article Abstract
Purpose Of Review: The purpose of this article is to describe the function of the vascular cell adhesion and signaling molecule, platelet/endothelial cell adhesion molecule-1 (PECAM-1), in endothelial cells, with special emphasis on its role in maintaining and restoring the vascular permeability barrier following disruption of the endothelial cell junction.
Recent Findings: In addition to its role as an inhibitory receptor in circulating platelets and leukocytes, PECAM-1 is highly expressed at endothelial cell-cell junctions, where it functions as an adhesive stress-response protein to both maintain endothelial cell junctional integrity and speed restoration of the vascular permeability barrier following inflammatory or thrombotic challenge.
Summary: Owing to the unique ability of antibodies that bind the membrane proximal region of the extracellular domain to trigger conformational changes leading to affinity modulation and homophilic adhesion strengthening, PECAM-1 might be an attractive target for treating vascular permeability disorders.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986701 | PMC |
| http://dx.doi.org/10.1097/MOH.0000000000000239 | DOI Listing |
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