Objective: Substance use in adulthood compromises work, relationships, and health. Prevention strategies in early adolescence are designed to reduce substance use and progressions to problematic use by adulthood. This report examines the long-term effects of offering Family Check-up (FCU) at multiple time points in secondary education on the progression of substance use from age 11 to 23 years.
Method: Participants (N = 998; 472 females) were randomly assigned individuals to intervention or control in Grade 6 and offered a multilevel intervention that included a classroom-based intervention (universal), the FCU (selected), and tailored family management treatment (indicated). Among intervention families, 23% engaged in the selected and indicated levels during middle school.
Results: Intention to treat analyses revealed that randomization to the FCU was associated with reduced growth in marijuana use (p < .05), but not alcohol and tobacco use. We also examined whether engagement in the voluntary FCU services moderated the effect of the intervention on substance use progressions using complier average causal effect (CACE) modeling, and found that engagement in the FCU services predicted reductions in alcohol, tobacco, and marijuana use by age 23. In comparing engagers with nonengagers: 70% versus 95% showed signs of alcohol abuse or dependence, 28% versus 61% showed signs of tobacco dependence, and 59% versus 84% showed signs of marijuana abuse or dependence.
Conclusion: Family interventions that are embedded within public school systems can reach high-risk students and families and prevent progressions from exploration to problematic substance use through early adulthood. (PsycINFO Database Record
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http://dx.doi.org/10.1037/a0040248 | DOI Listing |
Crit Rev Toxicol
January 2025
Syngenta, Bracknell, United Kingdom.
While progress has been made in recent years, there are still no suitable and accepted , or models that can be used to accurately predict whether a chemical substance has the intrinsic property to cause immune-mediated chemical respiratory allergy, typically manifested as allergic asthma or allergic rhinitis which represents a severe health hazard. Regulatory authorities have relied primarily on clinical evidence (case reports, clinical databases, worker exposure studies) to classify substances as respiratory sensitizers, but this evidence can lack a proven immunological mechanism which is necessary to identify substances which can cause life-long sensitization and clinically relevant allergic symptoms in the respiratory tract in an exposed population (such respiratory allergens may be considered as "true" sensitizers, in analogy to the definition of skin sensitization, and in contrast to respiratory irritants). In light of this, the European Center for Ecotoxicology and Toxicology of Chemicals convened a Task Force to evaluate the types of clinical methods and data sources and the implications of relying on such data for regulatory decision making from a scientific perspective.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Institute of Neurological Sciences, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Background: mRNAs are required to progress cellular processes such as synaptic plasticity and memory formation. Processing bodies (P-bodies) are storage units for mRNAs located at dendritic translation sites, so these mRNAs can participate in synaptic plasticity immediately when needed. P-bodies consist of 3 main proteins: DDX6, 4E-T, and LSM14A.
View Article and Find Full Text PDFAnal Chem
January 2025
State Key Laboratory of Silicate Materials for Architectures, Wuhan University of Technology, Wuhan 430070, China.
An in situ monitoring reaction can better obtain the variations during the progression of the photocatalytic reaction. However, the complexity of the apparatus and the limited applicability of substances are the common challenges faced by most in situ monitoring methods. Here, we invented an in situ infrared optical fiber sensor to monitor the reactants and products during photocatalytic reaction.
View Article and Find Full Text PDFCompr Rev Food Sci Food Saf
January 2025
Department of Food Science & Technology, School of Agriculture & Biology, Shanghai Jiao Tong University, Shanghai, China.
The food flavor science, traditionally reliant on experimental methods, is now entering a promising era with the help of artificial intelligence (AI). By integrating existing technologies with AI, researchers can explore and develop new flavor substances in a digital environment, saving time and resources. More and more research will use AI and big data to enhance product flavor, improve product quality, meet consumer needs, and drive the industry toward a smarter and more sustainable future.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
College of Medicine, Arab Academy For Science, Technology and Maritime Transport, New Alamein, Matrouh, Egypt.
Major depression has been affecting more than 280 million of the general population, and this number continue to rise. Thus, impairing daily life activities. Research on Major depression has been since the 19th century for the sake of elevating symptoms with less side effects.
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